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*Customized presentation for biological investigators with examples taken from current clinical trials in multiple disciplines.
Practical Biostatistics: A Step-by-Step Approach for Evidence-Based Medicine, Second Edition presents a complete resource of biostatistical knowledge meant for health sciences students, researchers and health care professionals. The book's content covers the investigator’s hypothesis, collective health, observational studies, the biostatistics of intervention studies, clinical trials and additional concepts. Chapters are written in a didactic way, making them easier to comprehend by readers with little or no background on statistics. Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision-making using statistical analyses of s...
Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision making. It is a practice that uses statistical analysis of scientific methods and outcomes to drive further experimentation and diagnosis. The profusion of evidence-based medicine in medical practice and clinical research has produced a need for life scientists and clinical researchers to assimilate biostatistics into their work to meet efficacy and practical standards. Practical Biostatistics provides researchers, medical professionals, and students with a friendly, practical guide to biostatistics. With a detailed outline of implementation steps complemented by a review o...
Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When perip...
BIOESTATÍSTICA PASSO A PASSO inclui o essencial sobre o tema para o profissional atuante emPesquisa Clínica, bem como para estudantes de graduação e todos aqueles dedicados à carreira acadêmica emsaúde.Nesta obra, o leitor assimilará, passo a passo, conceitos básicos como: • Ahipótese do investigador e o conceito de significância estatística (p) • FundamentosemSaúdeColetiva (Epidemiologia e Farmacoeconomia) • EstudosObservacionais • Ensaios Clínicos (estimativa do n,medidas de tendência central e de dispersão, intervalo de confiança etc) • Testes estatísticos • Índices de Risco e de Benefício • Estatística em Medicina de exames complementares (sensibilidade, especificidade, valor preditivo etc) • Revisões Sistemáticas eMetanálises • Correlação eRegressão • Análise per-protocolo e análise de intenção de tratar
Memoirs
Prático e objetivo, este compêndio oferece uma visão didática sobre os importantes aspectos da castanha-da-índia e associações, proporcionando uma compreensão atualizada dos assuntos mais relevantes da fitoterapia aplicada ao tratamento de alterações vasculares desencadeadas pela insuficiência venosa crônica.A farmacologia das plantas medicinais é uma excelente fonte de informações sobre espécies e moléculas derivadas que atuam e proveem maior estabilidade da parede venosa e da permeabilidade vascular, bem como o alívio sintomático clínico.?
This book comprehensively describes alkaptonuria and ochronosis. Beginning with the history, genetics, pathophysiology and diagnostics of the disease, the authors subsequently present a detailed characterization of its clinical manifestation in the spine, peripheral joints, eyes, ears, visceral organs and respiratory tract, its pathological anatomy and histology, as well as differential diagnosis. This is complemented by the latest data on therapy and experimental models of alkaptonuria, and supported by several case reports. Numerous pictures and radiological images document the clinical symptoms, giving the reader a solid understanding of the disease. On the basis of the editor’s and authors’ own extensive observations, the book offers an analysis of protein metabolism and aromatic amino acids in the context of alkaptonuria. Written by international experts in the field, the book offers a valuable reference guide for healthcare professionals working in rheumatology, dermatology, pulmonology, otolaryngology and histopathology.