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Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0
This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects. The first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2...
Encyclopedia of Astrobiology
Now in its third edition the Encyclopedia of Astrobiology serves as the key to a common understanding in the extremely interdisciplinary community of astrobiologists. Each new or experienced researcher and graduate student in adjacent fields of astrobiology will appreciate this reference work in the quest to understand the big picture. The carefully selected group of active researchers contributing to this work are aiming to give a comprehensive international perspective on and to accelerate the interdisciplinary advance of astrobiology. The interdisciplinary field of astrobiology constitutes a joint arena where provocative discoveries are coalescing concerning, e.g. the prevalence of exopla...
Brinkman's catalogus van boeken en tijdschriften
With 1901/1910-1956/1960 Repertoium is bound: Brinkman's Titel-catalohus van de gedurende 1901/1910-1956/1960 (Title varies slightly).
Brinkman's cumulatieve catalogus van boeken
Voorts een alphabetische lijst van Nederlandsche boeken in België uitgegeven.
Kingdom of the Netherlands
The staff report for the Netherlands’ 2009 Article IV Consultation describes the economic developments and policies. State interventions in the financial sector have been broadly appropriate and consistent with a sound fix-it-and-exit approach. Measures have included capital injections, nationalization, and government guarantees. Although systemic risks have been addressed effectively and risk-weighted capital ratios are above required minima, building up equity to levels deemed more adequate in regulatory reform proposals and brisker lending to support the economic recovery may require banks to tap considerable extra capital.
Mystery and Matter
Most of the scholarship regarding the Dutch monk and architect Dom Hans van der Laan OSB (1904-1991) has been narrowly focused on his architectural theory and projects. The liturgical and theological dimensions have been virtually neglected, though they are vital for a proper understanding of his thought. Through a thorough reading of the original sources, including previously unexplored documents from various archives, this book takes an interdisciplinary approach to Van der Laan’s theory. It brings together the different aspects of his work by studying both the liturgical-theological and architectural elements. On this basis the book offers a synthesis of the way in which Van der Laan was able to link earthly matter to the divine Mystery.
NMR Crystallography
The content of this volume has been added to eMagRes (formerly Encyclopedia of Magnetic Resonance) - the ultimate online resource for NMR and MRI. The term "NMR Crystallography" has only recently come into common usage, and even now causes raised eyebrows within some parts of the diffraction community. The power of solid-state NMR to give crystallographic information has considerably increased since the CPMAS suite of techniques was introduced in 1976. In the first years of the 21st century, the ability of NMR to provide information to support and facilitate the analysis of single-crystal and powder diffraction patterns has become widely accepted. Indeed, NMR can now be used to refine diffra...
Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, 2nd Edition
Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dime...
