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Drug Repurposing for Emerging Infectious Diseases and Cancer
This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.
Uncovering The Science Of Covid-19
The COVID-19 pandemic has disrupted lives and livelihoods all over the world by its myriad of twists and turns. The causative SARS coronavirus 2 continues to defy the imagination by its rapid evolution from the Alpha to Delta to Omicron variants. This book by an international and multi-disciplinary team of virologists, infectious diseases and public health physicians aims to uncover the scientific basis underpinning the virus characteristics, as well as the clinical and public health management of COVID-19. The ten chapters address and discuss a broad range of key topics including viral evolution, clinical management, diagnostic methodologies, aerosol transmission, public health containment measures, vaccination, pathophysiology, and omics analyses. More generally, the book can serve as a useful reference guide on many future scientific issues and questions that will continue to arise as humanity learns to confront and co-exist with COVID-19.
Molecular Biology of the SARS-Coronavirus
SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerability of our modern globalised world to the spread of a new emerging infection. SARS (or a similar new emerging disease) could neither have spread so rapidly nor had such a great global impact even 50 years ago, and arguably, it was itself a product of our global inter-connectedness. Increasing af?uence and a demand for wild-game as exotic food led to the development of large trade of live animal and game animal markets where many species o...
Journal of Virology
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Sharing the Sacred
The author looks at a place where the conditions for religious conflict are present, but active conflict is absent, focusing on a Muslim majority Punjab town (Malkerkotla) where both during the Partition and subsequently there has been no inter-religious violence.
