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Development of Antibody-Based Therapeutics
With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration. This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students.
Me & Rumi
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Development of Antibody-Based Therapeutics
Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ‘unit dose’ and ‘unit effect’ with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge w...
Innovative Perspectives in Oral and Maxillofacial Surgery
This book examines the latest technologies and developments in oral and maxillofacial surgery. It presents information in an easy-to-read format and meticulously details each surgical technique. Thorough and accurate chapters comprehensively present procedures and treatments step-by-step procedures objectively. Each chapter follows a consistent format of which includes the scientific documentation of the procedure through clinical studies, objective benefits for the patient, detailed explanations of the procedure, levels of treatment complexity according to the SAC (simple -advanced complex) classification, and cost-effectiveness of the procedure for the patient and clinician. Extensive images, figures, and tables supplement select chapters to aid in visual learning. Extensive and unique, Innovative Perspectives in Oral and Maxillofacial Surgery is a vital tool for all dental specialists ranging from undergraduate students to established oral maxillofacial surgeons.
Pharmacokinetics and Pharmacodynamics of Biotech Drugs
This first ever coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals meets the need for a comprehensive book in this field. It spans all topics from lead identification right up to final-stage clinical trials. Following an introduction to the role of PK and PD in the development of biotech drugs, the book goes on to cover the basics, including the pharmacokinetics of peptides, monoclonal antibodies, antisense oligonucleotides, as well as viral and non-viral gene delivery vectors. The second section discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. The final section considers the integration of PK and PD concepts into the biotech drug development plan, taking as case studies the preclinical and clinical drug development of tasidotin, as well as the examples of cetuximab and pegfilgrastim. The result is vital reading for all pharmaceutical researchers.
A Shi'ite Anthology
Created by the Prophet Muhammad and his twelve Imams, the Hadith is an ancient and profoundly influential body of religious texts in Shi'ite Muslim literature, second in importance only to the Holy Koran itself. Texts on the practical aspects of life and pure metaphysics are included in this first English translations of excerpts from the Hadith. Especially selected for the Western reader by the renowned Islamic scholar Tabataba'i, the passages from the Hadith shed light on the culture, history, law, and theology of the Shi'ite community and provide direct translations of some of the most famous of Islamic prayers.
The Book of Iran
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Development of Antibody-Based Therapeutics
With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration. This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students.
Shahnameh
The definitive translation by Dick Davis of the great national epic of Iran—now newly revised and expanded to be the most complete English-language edition A Penguin Classic Dick Davis—“our pre-eminent translator from the Persian” (The Washington Post)—has revised and expanded his acclaimed translation of Ferdowsi’s masterpiece, adding more than 100 pages of newly translated text. Davis’s elegant combination of prose and verse allows the poetry of the Shahnameh to sing its own tales directly, interspersed sparingly with clearly marked explanations to ease along modern readers. Originally composed for the Samanid princes of Khorasan in the tenth century, the Shahnameh is among t...
