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Development of Antibody-Based Therapeutics
Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ‘unit dose’ and ‘unit effect’ with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge w...
Development of Antibody-Based Therapeutics
With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration. This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students.
Me & Rumi
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Innovative Perspectives in Oral and Maxillofacial Surgery
This book examines the latest technologies and developments in oral and maxillofacial surgery. It presents information in an easy-to-read format and meticulously details each surgical technique. Thorough and accurate chapters comprehensively present procedures and treatments step-by-step procedures objectively. Each chapter follows a consistent format of which includes the scientific documentation of the procedure through clinical studies, objective benefits for the patient, detailed explanations of the procedure, levels of treatment complexity according to the SAC (simple -advanced complex) classification, and cost-effectiveness of the procedure for the patient and clinician. Extensive images, figures, and tables supplement select chapters to aid in visual learning. Extensive and unique, Innovative Perspectives in Oral and Maxillofacial Surgery is a vital tool for all dental specialists ranging from undergraduate students to established oral maxillofacial surgeons.
The Book of Iran
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A Shi'ite Anthology
Created by the Prophet Muhammad and his twelve Imams, the Hadith is an ancient and profoundly influential body of religious texts in Shi'ite Muslim literature, second in importance only to the Holy Koran itself. Texts on the practical aspects of life and pure metaphysics are included in this first English translations of excerpts from the Hadith. Especially selected for the Western reader by the renowned Islamic scholar Tabataba'i, the passages from the Hadith shed light on the culture, history, law, and theology of the Shi'ite community and provide direct translations of some of the most famous of Islamic prayers.
The Most Learned of the Shiʻa
The problem of who should succeed the Prophet has plagued the Islamic community since the time of his death. The Shiites have decided on a successor, but that does not solve who is the lawful marja (or grand ayatollah) of all the Shi'a.
Beholding Beauty
Beholding Beauty: Saʿdi of Shiraz and the Aesthetics of Desire in Medieval Persian Poetry explores the relationship between sexuality, politics, and spirituality in the lyrics of Saʿdi Shirazi (d. 1292 CE), one of the most revered masters of classical Persian literature. Relying on a variety of sources, including unstudied manuscripts, Domenico Ingenito presents the so-called “inimitable smoothness” of Saʿdi’s lyric style as a serene yet multifaceted window into the uncanny beauty of the world, the human body, and the realm of the unseen. The book constitutes the first attempt to study Sa‘di’s lyric meditations on beauty in the context of the major artistic, scientific and intellectual trends of his time. By charting unexplored connections between Islamic philosophy and mysticism, obscene verses and courtly ideals of love, Ingenito approaches Sa‘di’s literary genius from the perspective of sacred homoeroticism and the psychology of performative lyricism in their historical context.
Iranian Intellectuals in the Twentieth Century
Since the middle of the nineteenth century, Iranian intellectuals have been preoccupied by issues of political and social reform, Iran's relation with the modern West, and autocracy, or arbitrary rule. Drawing from a close reading of a broad array of primary sources, this book offers a thematic account of the Iranian intelligentsia from the Constitutional movement of 1905 to the post-1979 revolution. Ali Gheissari shows how in Iran, as in many other countries, intellectuals have been the prime mediators between the forces of tradition and modernity and have contributed significantly to the formation of the modern Iranian self image. His analysis of intellectuals' response to a number of fundamental questions, such as nationalism, identity, and the relation between Islam and modern politics, sheds new light on the factors that led to the Iranian Revolution—the twentieth century's first major departure from Western political ideals—and helps explain the complexities surrounding the reception of Western ideologies in the Middle East.
