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The Effect of Adjuvant Therapies on Long-term Outcome for Primary Resected Synovial Sarcoma in a Series of Mainly Children and Adolescents
Background: The benefit of adjuvant therapy in synovial sarcoma (SS) treatment is under debate. Long-term follow-up data are missing. Methods: SS patients treated in the consecutive trials CWS-81, CWS-86, CWS-91, CWS-96, CWS-2002-P, and the SoTiSaR-registry till 2013 were analyzed. Results: Median age of 185 patients was 13.9 years (0.1-56)--with median follow-up of 7.4 years for 163 survivors. Most tumors (76%) were located in extremities. Size was))3 cm in 58 (31%), 3-5 cm in 59 (32%), 5-10 cm in 42 (23%), and))10 cm in 13 (7%) (13 missing). In 84 (45%) tumors, first excision was complete (R0 corresponding to IRS-I-group) and in 101 (55%) marginal (R1 corresponding to IRS-II-group). In a s...
Pre-operative Radiotherapy is Associated with Superior Local Relapse-free Survival in Advanced Synovial Sarcoma
Purpose: Optimization of local therapies in synovial sarcoma (SS) considered unresectable at diagnosis is needed. We evaluated the effects of neoadjuvant versus adjuvant radiation versus surgery only on long-term outcomes. Methods: Patients with macroscopic SS tumors before chemotherapy (IRS-group-III) in the trials CWS-81, CWS-86, CWS-91, CWS-96, CWS-2002-P and SoTiSaR-registry were analyzed. Local therapies were scheduled after 3 neoadjuvant chemotherapy cycles. Results: Median age of 145 patients was 14.5 years. 106 survivors had median follow-up of 7.0 years. Tumor site was 96 extremities, 19 head-neck, 16 shoulder/hip, 14 trunk. Tumors were))3 cm in 16, 3-5 cm in 28, 5-10 cm in 55,))10 ...
Diagnostik und Therapie von Tumoren mit NTRK-Genfusionen
Abstract: NTRK-Genfusionen sind seltene genetische Alterationen, die tumorentitätenübergreifend vorkommen können. Während sie in den meisten soliden Tumoren nur sehr niederfrequent vorkommen, lassen sie sich in bestimmten Tumoren wie dem infantilen Fibrosarkom, dem kongenitalen mesoblastischen Nephrom und dem sekretorischen Mamma- oder Speicheldrüsenkarzinom jedoch häufig nachweisen. NTRK-Genfusionen bzw. TRK-Fusionsproteine gelten als starke onkogene Treiber. Bei Nachweis von NTRK-Genfusionen können TRK-Inhibitoren unabhängig von der Tumorentität eingesetzt werden. Vertreter sind Entrectinib und Larotrectinib. Bislang ist nur Larotrectinib in der Europäischen Union zugelassen. Fü...
The History of Emotions
The history of emotions is one of the fastest growing fields in current historical debate. This is an introduction to the field, synthesising the current research, and offering direction for future study, moving beyond the traditional debate between social constructivist and universalist theories of emotion.
Eloquent Bodies
A radical reassessment of the role of movement, emotion, and the viewing experience in Gothic sculpture Gothic cathedrals in northern Europe dazzle visitors with arrays of sculpted saints, angels, and noble patrons adorning their portals and interiors. In this highly original and erudite volume, Jacqueline E. Jung explores how medieval sculptors used a form of bodily poetics—involving facial expression, gesture, stance, and torsion—to create meanings beyond conventional iconography and to subtly manipulate spatial dynamics, forging connections between the sculptures and beholders. Filled with more than 500 images that capture the suppleness and dynamism of cathedral sculpture, often through multiple angles, Eloquent Bodies demonstrates how viewers confronted and, in turn, were addressed by sculptures at major cathedrals in France and Germany, from Chartres and Reims to Strasbourg, Bamberg, Magdeburg, and Naumburg. Shedding new light on the charismatic and kinetic qualities of Gothic sculpture, this book also illuminates the ways artistic ingenuity and technical skill converged to enliven sacred spaces.
Policing Transnational Protest
Policing Transnational Protest offers an original perspective on the history of police surveillance of anticolonial activists in France, Britain, and Germany in the first half of the twentieth century. Tracing the undertakings of anticolonial activists from Asia, Africa, and the Middle East in Europe and reconstructing the reaction of European governments, it illuminates the increasing cooperation of the police and secret services to monitor the activities of the "oriental revolutionaries" and curb their room to maneuver. But those efforts had an unintended inflammatory effect, provoking both supporters and opponents of colonial rule to understand the conflict in increasingly global and tran...
Enthusiasm
Enthusiasm seeks to contribute to a culturally and historically nuanced understanding of how emotions secure and ratify the truth of convictions. More than just pure affective intensity, enthusiasm is about something: a certainty, clarity, or truth. Neither as clearly negative as fanaticism nor as general as passion, enthusiasm specifically entails belief. For this reason, the book takes its starting point in religion, the social arena in which the concept was first debated and to which the term still gestures. Empirically based in modern German Protestantism, where religious emotion is intensely cultivated but also subject to vigorous scrutiny, it combines historical and ethnographic method...
Literature and Medicine
The experiences of health and illness, death and dying, the normal and the pathological have always been an integral part of literary texts. This volume considers how the two dynamic fields of medicine and literature have crossed over, and how they have developed alongside one another. It asks how medicine, as both science and practice, shapes the representation of illness and transforms literary form. It considers how literary texts across genres and languages of disease have put forward specific conceptions of medicine and impacted its practice. Taking into account the global, multilingual and multicultural contexts, this volume systematically outlines and addresses this double-sidedness of the literature-medicine connection. Literature and Medicine covers a broad spectrum of conceptual, thematic, theoretical, and methodological approaches that provide a solid foundation for understanding a vibrant interdisciplinary field.
Emotional Cities
Emotional Cities offers an innovative account of the history of cities in the second half of the nineteenth century. Analyzing debates about emotions and urban change, it questions the assumed dissimilarity of the history of European and Middle Eastern cities during this period. The author shows that between 1860 and 1910, contemporaries in both Berlin and Cairo began to negotiate the transformation of the urban realm in terms of emotions. Looking at the ways in which a variety of urban dwellers, from psychologists to bar maids, framed recent changes in terms of their effect on love, honor, or disgust, the book reveals striking parallels between the histories of the two cities. By combining urban history and the history of emotions, Prestel proposes a new perspective on the emergence of different, yet comparable cities at the end of the nineteenth century.
