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Beyond the Blueprint - Decoding the Elegance of Gene Expression
Beyond the Blueprint - Decoding the Elegance of Gene Expression is a captivating exploration into the fundamental processes that underpin the intricate workings of life itself. Delving deep into the realm of genetics, this book unveils the mesmerizing world of gene expression - the remarkable mechanism by which the information encoded in our DNA is translated into functional proteins and ultimately shapes every aspect of our being. With a keen focus on the crucial players in this symphony of life, readers will embark on a journey to uncover the core elements of gene expression. From the orchestration of transcription factors and RNA polymerases at promoter regions to the influence of epigene...
Bioinformatics Tools for Detection and Clinical Interpretation of Genomic Variations
Genomic variations and phenotypic diversity are closely linked and form the underlying mechanism for development of many human diseases. This book addresses the methods of detection, analysis, and interpretation of genomic variations in clinically relevant scenarios. If your research or clinical practice involves handling of genomic sequencing data, this book is for you. Topics covered include: methods for identifying genetic diversity, the workflow for analyzing whole exome and whole genome sequencing data, local ancestry deconvolution models, the value of molecular patterns and pattern biomarkers in cancer diagnosis and prognosis, and genotyping and profiling resistance-associated variants of hepatitis C. If your research or clinical practice involves handling of genomic sequencing data, this book is for you.
Polymerase Chain Reaction
This book is intended to present current concepts in molecular biology with the emphasis on the application to animal, plant and human pathology, in various aspects such as etiology, diagnosis, prognosis, treatment and prevention of diseases as well as the use of these methodologies in understanding the pathophysiology of various diseases that affect living beings.
Advances in the Diagnosis of Coronary Atherosclerosis
Coronary artery disease (CAD) and its consequences are most important morbidity and mortality reasons in the developed and developing countries. To prevent hard end-points, early definitive diagnosis and optimum therapy play significant role. Novel advanced diagnostic tests which are biomarkers of inflammation, cell adhesion, cell activation and imaging techniques provide to get the best result in the detection and characterization of calcified or uncalcified atherosclerotic plaques. In spite of last developments in the imaging methods, coronary catheterization is still frequently performed. Following the first cardiac catheterization performed in 1844, date by date historical developments and the mechanics of cardiac catheterization techniques, risks associated with coronary angiography, and also, preventions and treatments of possible complications have been presented in this book. Other important issue is radiation exposure of patients and staff during coronary angiography and scintigraphy. Radiation dose reduction techniques, general radiation protection principles have been discussed in related chapters.
Facility Location Planning in Relief Logistics: Decision Support for German Authorities
The delivery of essential goods to beneficiaries in the aftermath of a disaster is one of the main objectives of relief logistics. Thereby, the present work aims to improve relief logistics by improving the location selection of warehouses, distribution centers, and points of distribution. Consequently, it offers the potential to significantly improve the distribution of goods in the aftermath of future disasters and, thereby, increase disaster resilience.
Politics of Rightful Killing
In the early 2000s, mainstream international news outlets celebrated the growth of Weblogistan—the online and real-life transnational network of Iranian bloggers—and depicted it as a liberatory site that gave voice to Iranians. As Sima Shakhsari argues in Politics of Rightful Killing, the common assumptions of Weblogistan as a site of civil society consensus and resistance to state oppression belie its deep internal conflicts. While Weblogistan was an effective venue for some Iranians to “practice democracy,” it served as a valuable site for the United States to surveil bloggers and express anti-Iranian sentiment and policies. At the same time, bloggers used the network to self-polic...
Multi-objective Management in Freight Logistics
The second edition of Multi-Objective Management in Freight Logistics builds upon the first, providing a detailed study of freight transportation systems, with a specific focus on multi-objective modelling. It offers decision-makers methods and tools for implementing multi-objective optimisation models in logistics. The second edition also includes brand-new chapters on green supply chain and hybrid fleet management problems. After presenting the general framework and multi-objective optimization, the book analyses green logistic focusing on two main aspects: green corridors and network design; next, it studies logistic issues in a maritime terminal and route planning in the context of hazardous material transportation. Finally, heterogeneous fleets distribution and coordination models are discussed. The book presents problems providing the mathematics, algorithms, implementations, and the related experiments for each problem. It offers a valuable resource for postgraduate students and researchers in transportation, logistics and operations, as well as practitioners working in service systems.
Genetic Diversity and Disease Susceptibility
Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms.
Planning and Operation of Multi-Carrier Energy Networks
This book discusses the optimal design and operation of multi-carrier energy systems, providing a comprehensive review of existing systems as well as proposing new models. Chapters cover the theoretical background and application examples of interconnecting energy technologies such as combined heat and power plants, natural gas-fired power plants, power to gas technology, hydropower plants, and water desalination systems, taking into account the operational and technical constraints of each interconnecting element and the network constraint of each energy system. This book will be a valuable reference for power network and mechanical system professionals and engineers, electrical power engineering researchers and developers, and professionals from affiliated power system planning communities. Provides insight on the design and operation of multi-carrier energy systems; Covers both theoretical aspects and technical applications; Includes case studies to help apply concepts to real engineering situations.
