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Microbes as Tools for Cell Biology bridges the gap between cell biology and microbiology. This laboratory guide provides a microbial tool kit for biologists who wish to use microbes as probes for basic cellular functions. The volume is organized into three sections, covering essential information on culture and genetic manipulation of microbes, assays for pathogen-host recognition, and analysis of intracellular parasitism. Each chapter outlines practical procedures and describes the rationale behind their development. This volume should prove useful to anyone interested in the biology of infectious agents, or their exploitation as a new generation of cell biological reagents.Key Features* Introduction by renowned microbiologist Dr. Stanley Falkow* Covers manipulation of pathogens, especially generation and selection of non-virulent phenotypes* Guides researchers in the study of intracellular pathogenesis* Describes microbial adherence and phagocytosis assays* Focuses on protein trafficking in infected cells* Well-illustrated with color plates, halftones, and diagrams
The environmental devastation caused by military conflict has been witnessed in the wake of the Vietnam War, the Gulf War and the Kosovo conflict. This book brings together leading international lawyers, military officers, scientists and economists to examine the legal, political, economic and scientific implications of wartime damage to the natural environment and public health. The book considers issues raised by the application of humanitarian norms and legal rules designed to protect the environment, and the destructive nature of war. Contributors offer an analysis and critique of the existing law of war framework, lessons from peacetime environmental law, means of scientific assessment and economic valuation of ecological and public health damage, and proposals for future legal and institutional developments. This book provides a contemporary forum for interdisciplinary analysis of armed conflict and the environment, and explores ways to prevent and redress wartime environmental damage.
Biological Threats in the 21st Century offers a fresh understanding of contemporary biological threats to national security. Readers are introduced to the politics, people, science and historical roots of contemporary biological threats through up-to-date, rigorous and accessible chapters written by leading academics and supplemented by expert point-of-view contributions and interviews.The book provides inspiration and resources for students and researchers, as well as policy makers in government, the public policy sector and the wider community. It is particularly pertinent for those interested in biological disarmament, non-proliferation, counterterrorism and health security.
Documents relating to "NIH guidelines for research involving recombinant DNA molecules," Feb. 1975/June 1976- .
This completely revised and expanded Second Edition thoroughly examines tuberculosis from historical, theoretical, and clinical perspectives, including the most current discoveries. Containing 35 revised, rewritten, rearranged, and new chapters by nationally and internationally renowned experts, the updated Second Edition presents expande
Safeguarding U.S. agriculture from foreign animal diseases and protecting our food system require cutting-edge research and diagnostic capabilities. The Department of Homeland Security (DHS) and the U.S. Department of Agriculture (USDA) have embarked on an important mission to replace the aging Plum Island Animal Disease Center (PIADC) with a new facility, the National Bio- and Agro-Defense Facility (NBAF). When operational, this new facility would be the world's fourth biosafety level-4 laboratory capable of large animal research. It would serve as a critical world reference laboratory for identifying emerging and unknown disease threats, and would thus be a critical asset in securing the f...
This book describes the evolving CBRN risk landscape and highlights advances in the “core” CBRN technologies, including when combined with (improvised) explosive devices (CBRNe threats). It analyses how associated technologies create new safety and security risks, challenging certain assumptions that underlie current control regimes. The book also shows how technologies can be enablers for more effective strategies to mitigate these risks. 21st-century safety and security risks emanating from chemical, biological, radiological and nuclear materials – whether resulting from natural events, accidents or malevolent use - are increasingly shaped by technologies that enable their developmen...
This is the first full description of the public health consequences of war and of what health professionals can do to minimize these consequences and to help prevent war itself. The book covers the impact of war on public health, human rights, and the environment; the effects of specific weapons systems during war and the preparation for war; the effects of war and military activities on women, children, refugees, and other populations; the public health impacts of specific wars; and the role of health professionals and organizations during war and in preventing war. The book is well-illustrated with numerous figures and photographs, and is extensively referenced.
foreword by William S. Cohen, U.S. Secretary of Defense Biological weapons pose a horrifying and growing threat to the United States and to the world in general. Revelations about Iraq's weapons research and the plans of the Aum Shinrikyo cult in Japan serve as frightening reminders of the potential for military or terrorist use of biological agents. The essays in this book, many of which were originally published in the Journal of the American Medical Association, examine the medical, scientific, and political dimensions of limiting the threat posed by biological weapons. The contributors consider the current threat posed by biological weapons, the history of attempts to control them, episo...