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The number of cells within the human body is very tightly regulated: too many and we can develop cancer, too few and we may lose cells that we cannot replace. The number of cells is controlled by several different mechanisms in different tissues, but all are triggered to commit suicide should too many be in one place at one time, or become damaged. This book examines how this process of cell suicide (apoptosis) is regulated, and how our understanding of this process may lead to novel treatments for a wide variety of human diseases.
This text deals with concepts and experimental possibilities which could not have been anticipated 10 years ago. Recent hard evidence that neuronal cells in the central nervous system possess a capability for recovery after trauma well beyond that previously recognized poses many fundamental and secondary questions. For example: is there a programmed cell death phenomenon in the mature brain? Under what circumstances do neurotransmitters promote trophic responses in neurons or provoke cell death? How might environmental or toxic molecules be responsible for specific neuronal damage? conference on which this volume is partly based. Various additional invited papers are contained in this work on neuronal cell death and repair.
American Association for Cancer Research 2019 Proceedings: Abstracts 1-2748 - Part A
This volume incorporates practical methods at the level of molecular, cellular, and whole organism biology in vertebrate and invertebrate models. It presents straightforward protocols written step-by-step for state-of-the-art techniques with the emphasis on single-cell resolution procedures. - Provides straightforward, current protocols and critical appraisals - Includes diverse analysis of cellular and molecular techniques - Presents everything from whole-organ cultures to electrophysiological approaches - Details a variety of methods for interfering with gene function in various species - Offers multiple illusions of in situ hybridization, immunostaining, and apoptosis
To produce a comprehensive overview of macrophages and related cell types in a short review volume is an impossible task. When I selected the topics to be included, some equally important areas were omitted by necessity, and for this I apologize. My choices have been somewhat eclectic, touching subjects of personal interest (such as osteoclast biology and macrophage electrophysiology) or of current fashion (apopto sis, antigen processing, cell adhesion molecules). The book has also had to encompass areas of a more general flavor to provide balance for the general reader (such as reviews of macrophage development, heterogeneity, and function, and of the surface molecules expressed by macropha...
In apoptosis in the mammalian system, cells have a finite life - they develop, are used and then die. Cancer cells escape this programmed routine but, from an understanding of apoptosis, they can be programmed to die. This book addresses the
Vascular biology is at the forefront of much medical research, with links to many diseases.
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Available online or as a five-volume print set, The Blackwell Companion to Phonology is a major reference work drawing together 124 new contributions from leading international scholars in the field. It will be indispensable to students and researchers in the field for years to come. Key Features: Full explorations of all the most important ideas and key developments in the field Documents major insights into human language gathered by phonologists in past decades; highlights interdisciplinary connections, such as the social and computational sciences; and examines statistical and experimental techniques Offers an overview of theoretical positions and ongoing debates within phonology at the ...