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Melt Extrusion
This volume provides readers with the basic principles and fundamentals of extrusion technology and a detailed description of the practical applications of a variety of extrusion processes, including various pharma grade extruders. In addition, the downstream production of films, pellets and tablets, for example, for oral and other delivery routes, are presented and discussed utilizing melt extrusion. This book is the first of its kind that discusses extensively the well-developed science of extrusion technology as applied to pharmaceutical drug product development and manufacturing. By covering a wide range of relevant topics, the text brings together all technical information necessary to develop and market pharmaceutical dosage forms that meet current quality and regulatory requirements. As extrusion technology continues to be refined further, usage of extruder systems and the array of applications will continue to expand, but the core technologies will remain the same.
The Role of Microstructure in Topical Drug Product Development
Following the Semi-solid Microstructure Workshop sponsored by BASF and hosted by the Rutgers Center for Dermal Research, a pharmaceutical product development working group was formed. The group, known as the Q3 Working Group, selected the following five areas of focus: Particle/Globule Size and Distribution, Viscosity/Rheology/Spreadability, In Vitro Testing, State of API, State of Excipients. A committee was appointed for each of these five areas. The committees were tasked to review the literature, identify best practices, list experimental details required for an independent lab to duplicate the test, and propose scientific studies that may meaningfully advance this specific area of focus...
3D Printing
This inclusive text describes 3D Printing for pharmaceutical applications, including emerging 3D technologies. The book focuses on the functionality of the materials/biomaterials used for the preparation of dosage forms and devices, fundamentals for preparing these systems and novel applications using these additive manufacturing techniques. Also, the text includes clinical relevance and regulatory considerations for the future of personalized medicine. Authored by experts with a broad range of experience, extensive insight into the science of 3D printing technology used to produce these systems is provided. Highlighting viewpoints from the academic, polymer excipient, equipment, product development and regulatory communities, this comprehensive text compiles input from industry thought leaders to illustrate strategies and technologies for applying techniques of additive manufacturing for drug product and device development while also providing insight into the path forward for the technology in years to come.
3D Printing of Pharmaceuticals and Drug Delivery Devices
The 3D printing (3DP) process was patented in 1986; however, only in the last decade has it begun to be used for medical applications, as well as in the fields of prosthetics, bio-fabrication, and pharmaceutical printing. 3DP or additive manufacturing (AM) is a family of technologies that implement layer-by-layer processes in order to fabricate physical models based on a computer aided design (CAD) model. 3D printing permits the fabrication of high degrees of complexity with great reproducibility in a fast and cost-effective fashion. 3DP technology offers a new paradigm for the direct manufacture of individual dosage forms and has the potential to allow for variations in size and geometry as...
Country Reports on Human Rights Practices for 2008: Vols. I and II
Report submitted to the Committee on Foreign Relations, U.S. Senate, and the Committee on International Relations, U.S. House of Representatives, by the U.S. Dept. of State. These country reports on human rights cover the human rights practices of all nations that are members of the United Nations and a few that are not. They are printed to assist members of Congress in the consideration of legislation, particularly foreign assistance legislation
The Brief, Madcap Life of Kay Kendall
Comedic film actress Kay Kendall, born to a theatrical family in Northern England, came of age in London during the Blitz. After starring in Britain's biggest cinematic disaster, she found stardom in 1953 with her brilliant performance in the low-budget film, Genevieve. She scored success after success with her light comic style in movies such as Doctor in the House, The Reluctant Debutante, and the Gene Kelly musical Les Girls. Kendall's private life was even more colorful than the plots of her films as she embarked on a series of affairs with minor royalty, costars, directors, producers, and married men. In 1954 she fell in love with her married Constant Husband costar Rex Harrison and acc...
