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Computational Toxicology
Humans are exposed to chemicals through voluntary and involuntary actions; to natural and synthetic chemicals all day, every day. Single chemical risk assessments are complex in and of themselves, and the assessment of chemical mixtures exponentially increases the complexity for toxicologists, regulators, and the public. Chemicals produce effects in biological systems which may or may not be related to their toxicity; some effects may be adaptive or may not be a direct part of their mode or mechanism of toxic action. These terms are commonly used and may be distinguished based on the level of detail implied. Mode of action usually describes the effect of a toxicant at the cellular or organ level, while mechanism of action implies an understanding of the interaction of the toxicant at the molecular level. Chemicals can have the same mode of action, but act via different mechanisms. Components in a chemical mixture are characterized by mode and/or mechanism for the purpose of grouping, described later.
Handbook on the Toxicology of Metals
Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers “General Conside...
Environmental Health Sciences Decision Making
Environmental health decision making can be a complex undertaking, as there is the need to navigate and find balance among three core elements: science, policy, and the needs of the American public. Policy makers often grapple with how to make appropriate decisions when the research is uncertain. The challenge for the policy maker is to make the right decision with the best available data in a transparent process. The Environmental Health Sciences Decision Making workshop, the first in a series, was convened to inform the Roundtable on Environmental Health Sciences, Research, and Medicine on emerging issues in risk management, "weight of evidence," and ethics that influence environmental health decision making. The workshop, summarized in this volume, included an overview of the principles underlying decision making, the role of evidence and challenges for vulnerable populations, and ethical issues of conflict of interest, scientific integrity, and transparency. The workshop engaged science interest groups, industry, government, and the academic sector.
Computational Toxicology
Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided in this book are based on cutting-edge technologies and set out to stimulate the ...
Handbook on the Toxicology of Metals: Volume I: General Considerations
Handbook on the Toxicology of Metals, Fifth Edition, Volume I: General Considerations is the first volume of a two-volume work that gives an overview and covers topics of general importance including reviews of various health effects of trace metals. The book emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology and contains several new chapters. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, phar...
Handbook on the Toxicology of Metals: Volume II: Specific Metals
Handbook on the Toxicology of Metals, Volume II: Specific Metals, Fifth Edition provides complete coverage of 38 individual metals and their compounds. This volume is the second volume of a two-volume work which emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health. - Contains peer-reviewed chapters that deal with the effects of metallic elements and their compounds on biological systems with a focus on human health effects - Includes information on sources, transport, and the transformation of metals in the environment - Provides critical information on the properties, use, biological monitoring, dose-response relationships, diagnosis, treatment, and prevention of 38 metallic elements and their compounds
Under the Magnolias
This night not only marked the end to the drought, but also the end to the long-held secret we'd kept hidden under the magnolias. Magnolia, South Carolina, 1980 Austin Foster is barely a teenager when her mama dies giving birth to twins, leaving her to pick up the pieces while holding her six siblings together and doing her best to stop her daddy from retreating into his personal darkness. Scratching out a living on the family's tobacco farm is as tough as it gets. When a few random acts of kindness help to ease the Fosters' hardships, Austin finds herself relying upon some of Magnolia's most colorful citizens for friendship and more. But it's next to impossible to hide the truth about the g...
The Year in Television, 2008
In 2008, the broadcast networks, cable channels and syndication produced nearly 1,100 new and continuing entertainment programs—the most original productions in one year since the medium first took hold in 1948. This reference book covers all the first run entertainment programs broadcast over the airwaves and on cable from January 1 through December 31, 2008, including series, specials, miniseries, made-for-television movies, pilot films, Internet series and specialized series (those broadcast on gay and lesbian channels). Alphabetically arranged entries provide storylines, performer/character casts, production credits, day/month/year broadcast dates, type, length, network(s), and review excerpts.
Under the Tulip Tree
Sixteen-year-old Lorena Leland's dreams of a rich and fulfilling life as a writer are dashed when the stock market crashes in 1929. Seven years into the Great Depression, Rena's banker father has retreated into the bottle, her sister is married to a lazy charlatan and gambler, and Rena is an unemployed newspaper reporter. Eager for any writing job, Rena accepts a position interviewing former slaves for the Federal Writers' Project. There, she meets Frankie Washington, a 101-year-old woman whose honest yet tragic past captivates Rena. As Frankie recounts her life as a slave, Rena is horrified to learn of all the older woman has endured--especially because Rena's ancestors owned slaves. While Frankie's story challenges Rena's preconceptions about slavery, it also connects the two women whose lives are otherwise separated by age, race, and circumstances. But will this bond of respect, admiration, and friendship be broken by a revelation neither woman sees coming?
A Park to Yourself
The goal of A Park to Yourself is to inspire great adventures for every type of visitor to America's National Parks: first-timers and frequent travelers, RVers and tent campers, families and solo trekkers, backpackers and daytrippers, thrill-seekers and photographers, and everyone in between. We cover all 61 designated National Parks in the United States, 50 of them in depth with descriptions of the best places to hike, take photos, and see wildlife. If you are camping in a tent, RV, or prefer not to camp at all, we include the logistics you need to know. We identify the peak months of visitation and the busiest places in each park, whether you are attracted to those spots or want to avoid t...
