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Memory T Cells
Immunological memory has fascinated microbiologists and immunologists for decades as one of the new frontiers to conquer to better understand the response to pathogens, cancer and vaccination. Over the past decade, attention has turned to the intrinsic properties of the memory T cells themselves, as it has become clear that the eradication of both infected cells and tumors requires T cells. This book is an attempt to capture the wave of discoveries associated with these recent studies. Its chapters represent a wide collection of topics related to memory T cells by laboratories that have invested their skills and knowledge to understand the biology and the principles upon which memory T cells are generated, maintained and expanded upon re-encounter with antigen. Ultimately, these studies are all aimed at a better understanding of the function of memory T cells in protection against disease.
Molecular Vaccines
This title discusses all aspects of non-infectious and non-cancer– so called NINC – vaccines. Hypertension, diabetes and allergy vaccine development are referred to as well as the use of adjuvants and nanotechnology in vaccine development. The way of novel vaccines from bench to preclinical to clinical studies and launch to the market under EMEA (European Medicines Agency) and FDA (Food and Drug Administration) guidelines are described in-depth. The book is therefore of interest for researchers and clinicians engaged in vaccine development and molecular vaccine application.
Stochastic Regulation of the Interleukin-4 Gene
This book focuses on the expression variability of highly regulated genes in multi-cellular organisms through a multidisciplinary approach combining quantitative measurements and mathematical modeling. For this purpose, the cytokine gene Interleukin-4 (IL-4) in murine type-2 (Th2) lymphocytes was chosen as prototypical model system of an inducible gene regulated at the epigenetic and transductional level. As many cytokines, IL-4 is expressed in a probabilistic manner, but the underlying molecular mechanisms behind this phenomenon are still unresolved. Through an iterative process of quantitative measurements and mathematical analysis, the author develops a computational model able to predict...
Parable of the Sower
This acclaimed post-apocalyptic novel of hope and terror from an award-winning author "pairs well with 1984 or The Handmaid's Tale" and includes a foreword by N. K. Jemisin (John Green, New York Times). When global climate change and economic crises lead to social chaos in the early 2020s, California becomes full of dangers, from pervasive water shortage to masses of vagabonds who will do anything to live to see another day. Fifteen-year-old Lauren Olamina lives inside a gated community with her preacher father, family, and neighbors, sheltered from the surrounding anarchy. In a society where any vulnerability is a risk, she suffers from hyperempathy, a debilitating sensitivity to others' emotions. Precocious and clear-eyed, Lauren must make her voice heard in order to protect her loved ones from the imminent disasters her small community stubbornly ignores. But what begins as a fight for survival soon leads to something much more: the birth of a new faith . . . and a startling vision of human destiny.
