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The Economics of Environmental Risk
Featuring real world examples of how risk information affects public choices, The Economics of Environmental Risk expertly demonstrates that policymakers need to consider how people learn about those risks. Offering insights into examples such as hazardous waste, radon, smoking, hurricanes and terrorist threats over the past four decades, this intuitive book illustrates environmental risks and the choices made to mitigate the potential effects.
Genetic Studies of Paired Metabolomes Reveal Enzymatic and Transport Processes at the Interface of Plasma and Urine
Abstract: The kidneys operate at the interface of plasma and urine by clearing molecular waste products while retaining valuable solutes. Genetic studies of paired plasma and urine metabolomes may identify underlying processes. We conducted genome-wide studies of 1,916 plasma and urine metabolites and detected 1,299 significant associations. Associations with 40% of implicated metabolites would have been missed by studying plasma alone. We detected urine-specific findings that provide information about metabolite reabsorption in the kidney, such as aquaporin (AQP)-7-mediated glycerol transport, and different metabolomic footprints of kidney-expressed proteins in plasma and urine that are consistent with their localization and function, including the transporters NaDC3 (SLC13A3) and ASBT (SLC10A2). Shared genetic determinants of 7,073 metabolite-disease combinations represent a resource to better understand metabolic diseases and revealed connections of dipeptidase 1 with circulating digestive enzymes and with hypertension. Extending genetic studies of the metabolome beyond plasma yields unique insights into processes at the interface of body compartments
Nordic urban nature recreation
The Nordic countries continue to experience growth of urban areas, which provides benefits like economic growth, but also imposes economic costs in terms of reduced ecosystem services. This report focuses on urban nature recreation and highlights economic methods and data that can help capture the associated nonmarket welfare benefits. The study stresses the need to collect user data to better understand visitation patterns, which can be combined with valuation methods to provide evidence of economic benefits associated with e.g., hiking, cycling, skiing, paddling and other recreation activities. Once these benefits are visible, decision-makers will have a better basis to balance economic growth with the environmental costs it imposes on urban ecosystem services.
SLC26A1 is a Major Determinant of Sulfate Homeostasis in Humans
Abstract: Sulfate plays a pivotal role in numerous physiological processes in the human body, including bone and cartilage health. A role of the anion transporter SLC26A1 (Sat1) for sulfate reabsorption in the kidney is supported by the observation of hyposulfatemia and hypersulfaturia in Slc26a1-knockout mice. The impact of SLC26A1 on sulfate homeostasis in humans remains to be defined. By combining clinical genetics, functional expression assays, and population exome analysis, we identify SLC26A1 as a sulfate transporter in humans and experimentally validate several loss-of-function alleles. Whole-exome sequencing from a patient presenting with painful perichondritis, hyposulfatemia, and r...
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The Whispers of War
For fans of historical novels by Kristin Harmel and Martha Hall Kelly comes a “gripping tale by a writer at the top of her game” (Fiona Davis, author of The Chelsea Girls) following three friends who struggle to remain loyal as one of them is threatened with internment by the British government at the start of World War II. In August of 1939, as Britain watches the headlines in fear of another devastating war with Germany, three childhood companions must choose between friendship and country. Erstwhile socialite Nora is determined to find her place in the Home Office’s Air Raid Precautions Department, matchmaker Hazel tries to mask two closely guarded secrets with irrepressible optimis...
Erinnerung
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Obstacles to Environmental Progress
Why, when so many people understand the severity of environmental problems, is progress so slow and sustainability such a distant goal? What gets in the way? Perhaps you have immediately thought of several barriers. In Obstacles to Environmental Progress, Peter Schulze identifies 18 practical obstacles that routinely and predictably hinder U.S. progress on existing environmental problems. The obstacles apply to problems small and large and, in most cases, regardless of whether an issue is controversial. Though the book focuses on the U.S., most of the obstacles pertain elsewhere as well. The obstacles fall into three categories: scientific challenges to anticipating and detecting problems; p...
