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This book reviews the therapeutic developments in clinical trial design that have resulted in new treatment options for patients suffering from MS. Important ethical considerations that arise with the new treatments are included, as well as the perspective on the emergence of MS as a treatable disease.
Articles with reference to the state of Rajasthan, India.
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It has been recognized that viruses can induce neuronal damage by a variety of mechanisms. This volume summarizes, for the first time, the various ways that neurons can degenerate under the influence of viral infection, ranging from acute necrosis and virus-induced apoptosis to chronic damage in persistent infections. The mechanisms of neuronal latency are dealt with as well. The volume also includes chapters that review the chronic damage caused by viral proteins that interfere with differentiated functions of the neuron, including signaling by neurotransmitters and signal transduction by trophic factors. Other chapters deal with the controversial role of cellular immune reactions, which may be helpful in controlling infection, but may also be detrimental to the host nervous system. The specific mechanisms of damage involved in retroviral infections and in prion diseases of the nervous system are reviewed, and finally how autoimmune diseases can lead to neuronal damage.
Addressing an important gap in the historiography of modern Assam, this book traces the relatively unexplored but profound transformations in the agrarian landscape of late- and post-colonial Assam that were instrumental in the making of modern Assamese peasantry and rural politics. It discusses the changing relations between various sections of peasantry, state, landed gentry, and politics of different ideological hues — nationalist, communist and socialist — and shows how a primarily agrarian question concerning peasantry came to occupy the centre stage in the nationalist politics of the state. It will especially interest scholars of history, agrarian and peasant studies, sociology, and contemporary politics, as also those concerned with Northeast India.
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