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Once Upon a Future Time
An in-depth study of Buddhist theories of the decline and disappearance of their own religion. Nattier's work challenges previous assumptions on this topic and focuses on the critical study of the "Kausambi Story, " a Buddhist prophecy of decline, in its Tibetan, Central Asian, and Chinese variants.
Mechanism of Action of Antieukaryotic and Antiviral Compounds
When Antibiotics I was published in 1967, the teleological view was held by some that" antibiotics" were substances elaborated by certain microorgan isms for the purpose of competing with other microorganisms for survival in mixed ecological environments. However, not only had J. EHRLICH and his associates shown 15 years earlier that chloramphenicol was produced by Strepto myces venezuelae in cultures of sterilized soils but not in parallel cultures of the same soils which were not sterilized, but operationally, the search for anti cancer antibiotics was actively under way (Antibiotics I reporting on numerous such substances), although the concept of antibiosis could not logically justify su...
Nucleic Acid Polymerases: The Two-Metal-Ion Mechanism and Beyond
olymerases are the nucleotidyl transferases that are responsible for synthesizing DNA and RNA. They are crucial for essential cellular processes including cellular and viral genome replication, DNA repair and damage tolerance, and transcription. Consistent with their vital roles, polymerases are found in all domains of life. The overall chemistry employed by these enzymes is conserved but there are variations among the different groups of polymerases that confer different substrate specificities and nucleotide incorporation fidelities that allow them to be involved in a wide array of cellular activities. Since polymerases were first isolated more than six decades ago, we have made great progress in understanding how different polymerases have adapted to their specific roles. In this Research Topic we will focus on the enzymatic mechanisms of these enzymes and the relationships between polymerase structure and mechanism, to highlight common themes and unique adaptations.
DNA Damage, DNA Repair and Disease Volume 2
The overall aim of these books is to give scientists in academia and industry a comprehensive overview of the field of DNA damage and DNA repair and related human diseases.
