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Auxiliary Verb Constructions in Altai-Sayan Turkic
Auxiliary Verb Constructions in Altai-Sayan Turkic is a comprehensive survey of the rich system of auxiliary verbs found in the Altai-Sayan Turkic languages spoken in south central Siberia. This includes a discussion of the range of patterns of inflection in the auxiliary verb constructions, the development of various verbal affixes that were originally auxiliary verbs, and the wide array of functions that auxiliary verb constructions have in this group of languages. These latter include the usual tense, mood, and aspect categories that are commonly associated with auxiliary verbs across the languages of the world. In addition, auxiliary verb constructions have several less typical functions in the Altai-Sayan Turkic languages. These include both unusual modal or aspectual categories like unexpected action or 'pretend to' forms and categories relating to so-called verbal 'orientation' or 'direction' and 'version'. In the former instance, the forms mark motion toward or away from the subject, topic, or discourse locus, while the latter formations indicate whether a subject or a nonsubject is the participant primarily affected by the action of the verb.
Gradient Flows
The book is devoted to the theory of gradient flows in the general framework of metric spaces, and in the more specific setting of the space of probability measures, which provide a surprising link between optimal transportation theory and many evolutionary PDE's related to (non)linear diffusion. Particular emphasis is given to the convergence of the implicit time discretization method and to the error estimates for this discretization, extending the well established theory in Hilbert spaces. The book is split in two main parts that can be read independently of each other.
Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins
TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifier...
