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Gene Therapy Studies of Adenoviral IL-10 Transduced Dendritic Cells in Allotransplantation
Studies the capacity of dendritic cells transduced with the immunosuppressive gene construct adenoviral interleukin-10 to inhibit alloimmune responses in both small and large animal transplantation models. There is promising in vitro evidence for gene therapy to modify dendritic cell function, which in small animal models can modify skin graft rejection. In large animals, genetically modified dendritic cells alone were not capable of prolongation of allograft survival, suggesting that these cells may require adjuvant immunosuppressive therapy to be used in future protocols.
Coates's Herd Book
None
Uneasy Peace
From the late ’90s to the mid-2010s, American cities experienced an astonishing drop in violent crime, dramatically changing urban life. In many cases, places once characterized by decay and abandonment are now thriving, the fear of death by gunshot wound replaced by concern about skyrocketing rents. In Uneasy Peace, Patrick Sharkey, “the leading young scholar of urban crime and concentrated poverty” (Richard Florida, author of The Rise of the Creative Class and The New Urban Crisis) reveals the striking effects: improved school test scores, because children are better able to learn when not traumatized by nearby violence; better chances that poor children will rise into the middle cla...
Bold Palates
Bold Palates is lovingly researched and extensively illustrated. Barbara Santich helps us to a deeper understanding of Australian identity by examining the way we eat. Not simply a gastronomic history, her book is also a history of Australia and Australians.
