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Immunobiology of Organ Transplantation
Currently, individuals interested in seeking an in-depth discussion of transplantation immunology must seek individual articles published in several journals, or extrapolate information from various non-transplant immunology textbooks. The purpose of this text is to provide the reader with a single source of information for the basic science of immunobiology of organ transplantation. It is unique that it focuses on immunobiology from the basic research side, with an emphasis on the cellular and molecular levels. The readers will be physicians, scientists, and graduate students interested and engaged in the study of immunology as it relates to allo- and xenotransplantation. This book is designed to be the reference standard for the immunobiology of transplantation.
Heme Oxygenase
Heme oxygenase is an enzyme which breaks down heme, the iron-containing oxygen-carrying constituent of the red blood cells. Heme must be synthesised and degraded within an individual nucleated cell, as heme is essential for the maintenance of cellular homeostasis by sensing or using oxygen. Physiological heme degradation is catalysed by the two functional isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, yielding CO, iron, and biliverdin IX N. Heme oxygenase-1 (HO-1), has potent anti-inflammatory, anti-oxidant and anti-proliferative effects, is up-regulated by multiple stimuli and provides protection against oxidative stress. HO-1 also plays an important role in the regulation of cardiovascular function and is involved in many other diseases such as sickle cell disease. This new book brings together leading research from around the world in this field.
Merchant Vessels of the United States
From 1894/95-1935/36, pt.6 of each volume is issued separately, with titles, 1894/95-1902/03: Code list of merchant vessels of the United States; 1903/04-1935/36: Seagoing vessels of the United States.
MIF Family Cytokines in Innate Immunity and Homeostasis
The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.
Signal Transduction and the Gasotransmitters
Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions...
Hazzard's Geriatric Medicine and Gerontology, Eighth Edition
The undisputed leader on the subject of geriatrics—updated to reflect the most recent advances in the field A Doody's Core Title for 2024 & 2023! The leading text on the subject of geriatrics, this comprehensive guide combines gerontology principles with clinical geriatrics, offering unmatched coverage of this area of medicine. Anchored in evidence-based medicine and patient-centered practice, Hazzard's Geriatric Medicine and Gerontology presents the most up-to-date, medical information available. This updated eighth edition reflects the continued growth and increasing sophistication of geriatrics as a defined medical discipline. The book focuses on the implementation of key concepts and c...
