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Cell lineages derived from common lymphoid progenitors (CLPs) play a critical role in antigen recognition, acute and long term protection against pathogens, and maintenance of immune homeostasis. CLPs give rise to adaptive immune cells that bear unique antigen receptors and to innate immune cells that perform non-redundant roles, particularly during early effector responses, by facilitating local immunity and shaping the ensuing adaptive response. Recent discoveries indicate that innate lymphoid cells (ILCs) exert essential modulatory effects in normal and pathological responses. Because adaptive and innate lymphoid cells share transcription factors, cytokines, and molecular surface markers,...
Regulatory T cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic aspects. In particular, this book deals with the various Treg based mechanisms which can lead to autoimmune diseases and covers the different aspects of linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies. The book specifically focuses on the Treg based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood & blood vessel, and eye diseases and aims to provide a mus...
After decades of bloodshed and political terror, many lament the rise of the left in Latin America. Since the triumph of Castro, politicians and historians have accused the left there of rejecting democracy, embracing communist totalitarianism, and prompting both revolutionary violence and a right-wing backlash. Through unprecedented archival research and gripping personal testimonies, Greg Grandin powerfully challenges these views in this classic work. In doing so, he uncovers the hidden history of the Latin American Cold War: of hidebound reactionaries holding on to their power and privilege; of Mayan Marxists blending indigenous notions of justice with universal ideas of equality; and of ...
The Geography of Bliss membawa pembaca melanglangbuana ke berbagai negara, dari Belanda, Swiss, Bhutan, hingga Qatar, Islandia, India, dan Amerika ... untuk mencari kebahagiaan. Buku ini adalah campuran aneh tulisan perjalanan, psikologi, sains, dan humor. Ditulis tidak untuk mencari makna kebahagiaan, tapi di mana. Apakah orang-orang di Swiss lebih bahagia karena negara mereka paling demokratis di dunia? Apakah penduduk Qatar, yang bergelimang dolar dari minyak mereka, menemukan kebahagiaan di tengah kekayaan itu? Apakah Raja Bhutan seorang pengkhayal karena berinisiatif memakai indikator kebahagiaan rakyat yang disebut Gross National Happiness sebagai prioritas nasional? Kenapa penduduk As...
This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.
FROM THE PREFACE: The abundance of insects can change dramatically from generation to generation; these generational changes may occur within a growing season or over a period of years. Such extraordinary density changes or "outbreaks" may be abrupt and ostensibly random, or population peaks may occur in a more or less cyclic fashion....The goal of this book is to update and advance current thinking on the phenomenon of insect outbreaks. The contributors have reviewed relevant literature in order to generate a synthesis providing new concepts and important alternatives for future research. More importantly, they have presented new ideas or syntheses that will stimulate advances in thinking and experimentation.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
An acclaimed travel writer examines the connection between surroundings and innovative ideas, profiling examples in such regions as early-twentieth-century Vienna, Renaissance Florence, ancient Athens, and Silicon Valley. --Publisher.