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Mitochondria in Liver Disease
" excellent, well-organized, and timely."-Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series PrefaceThe liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range
Management of Dyslipidemia
Dyslipidemia is a major risk factor for cardiovascular events, cardiovascular mortality, and all-cause mortality. The earlier in life dyslipidemia is treated, the better the prognosis. The current book is an excellent one on dyslipidemia written by experts on this topic. This book includes 12 chapters including 5 on lipids, 4 on hypercholesterolemia in children, and 3 on the treatment of dyslipidemia. This book should be read by all health care professionals taking care of patients, including pediatricians since atherosclerotic cardiovascular disease begins in childhood.
Cancer and Aging
Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment option...
Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies
This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.
Pan-genomics: Applications, Challenges, and Future Prospects
Pan-genomics: Applications, Challenges, and Future Prospects covers current approaches, challenges and future prospects of pan-genomics. The book discusses bioinformatics tools and their applications and focuses on bacterial comparative genomics in order to leverage the development of precise drugs and treatments for specific organisms. The book is divided into three sections: the first, an "overview of pan-genomics and common approaches, brings the main concepts and current approaches on pan-genomics research; the second, “case studies in pan-genomics, thoroughly discusses twelve case, and the last, “current approaches and future prospects in pan-multiomics , encompasses the development...
Abiotic Stress-Mediated Sensing and Signaling in Plants: An Omics Perspective
The natural environment for plants is composed of a complex set of abiotic and biotic stresses; plant responses to these stresses are equally complex. Systems biology allows us to identify regulatory hubs in complex networks. It also examines the molecular “parts” (transcripts, proteins and metabolites) of an organism and attempts to combine them into functional networks or models that effectively describe and predict the dynamic activities of that organism in different environments. This book focuses on research advances regarding plant responses to abiotic stresses, from the physiological level to the molecular level. It highlights new insights gained from the integration of omics data...
Botanical Leads for Drug Discovery
Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical indust...
Cactus and Succulent Plants
Found in a variety of forms, cacti and other succulents have elicited widespread interest and tremendous popularity worldwide. Although the subject of a certain amount of debate, about 10,000 species are recognized as belonging to the succulent group. Of these, an estimated 2,000 are threatened with global extinction in the wild and many more are regionally or nationally threatened mainly due to habitat destruction and collection for international trade.This Action Plan brings together from around the world current information on population status, threats and conservation of this particularly important group of plants. Prepared with conservationists, scientists, governments, protected area managers and grant-awarding bodies in mind, it suggests priorities for action and encourages collaboration among interested parties at all levels.
'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine
This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.
Advances in Bioremediation and Phytoremediation for Sustainable Soil Management
This edited volume deals with the understanding of the issues concerned with the pollution caused by toxic elements and heavy metals and their impacts on the different agro-ecosystems as well as the techniques involved in sustainable remediation and amelioration of polluted soils. Furthermore, the book is a detailed comprehensive account for the treatment technologies from unsustainable to sustainable which includes chapters prepared by professionals with expertise in environmental microbiology, biotechnology, bioremediation, and environmental engineering. It focuses on the characterization, reclamation, bioremediation, and phytoremediation of polluted soils. The research presented also highlights some of the significantly important plant and microbial species involved in remediation, the physiology, biochemistry, and the mechanisms of remediation by various plants and microbes, and suggestions for future improvement of bioremediation technology. It offers insights into the current focus and recent advances in bioremediation and green technology applications for sustainable soil management.
