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This authoritative volume describes the role of free radicals and antioxidants in prenatal and perinatal disorders currently explored in clinical and pre-clinical trials. In twenty-two inclusive chapters, the book covers the gamut of oxidative stress and its relation to a variety of factors, including fertility, metabolism, redox biomarkers, antioxidant defense and protection, gene polymorphisms, angiogenesis, cell signaling, mutations and oxidative damage involving lipids, proteins and nucleic acids, membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function, hypoxia, and post-natal stressors. This comprehensive source will keep clinicians and research scientists up-to-date on translational research into medical applications. Perinatal and Prenatal Disorders is a significant addition to the well-known Oxidative Stress in Applied Basic Research and Clinical Practice series.
The Vanishing of Carolyn Wells is the first biography of one of the “lost ladies” of detective fiction who wrote more than eighty mysteries and hundreds of other works between the 1890s and the 1940s. Carolyn Wells (1862–1942) excelled at writing country house and locked-room mysteries for a decade before Agatha Christie entered the scene. In the 1920s, when she was churning out three or more books annually, she was dubbed “about the biggest thing in mystery novels in the US.” On top of that, Wells wielded her pen in just about every literary genre, producing several immensely popular children’s books and young adult novels; beloved anthologies; and countless stories, prose, and ...
This is the first full and up-to-date survey of Aegean archaeology at the beginning of the Iron Age (late eleventh and tenth centuries BC) since Snodgrass's classic The Dark Age of Greece (1971). These crucial 150 years in the development of ancient Greek society are known as the Protogeometric period after the characteristic pottery which was commonly in use in the Aegean. The book offers a detailed account of old and new discoveries with chapters on pottery, metal finds, burial customs, and architectural remains (and how to use them to understand the social and political structure of the society). This analysis of the material culture of the period covers not only well-known sites such as ...
The field of ecosystem health explores the interactions between natural systems, human health, and social organization. As decision makers require a sound, modular approach to environmental management and sustainable development, ecosystem health assessment indicators are increasingly used across any number of applications. The Handbook of Ecologic
This broad review is the first to gather comprehensive information on the complete contemporary range of toxicity testing procedures and hazard assessment procedures, which is normally scattered and difficult to find. The two-volume set provides a consistent, template-based approach, linking relevant information on background, theory and practice to each bioassay. Volume 1 covers small-scale toxicity test methods. Includes extensive glossary.
From the contents: · C. Brater and M. D. Murray: The effects of NSAIDs on the kidney · G. Edwards and A. H. Weston: Latest developments in potassium channel modulator drugs · M.R. Juchau and Y. Huang: Chemical teratogenesis in humans: Biochemical and molecular mechanisms · S.P. Gupta: Studies on cardiovascular drugs · G. Polak: Antifungal chemotherapy: An everlasting battle · O. Valdenaire: New insights into the bioamine receptor family.
While major oil spills are rare, oil slicks can have disastrous environmental and economic consequences. This book summarizes research on the use of chemical dispersants: their effectiveness and limitations and the results of using them in different spill situations. Based on laboratory and field research as well as on actual case histories, this book contains a clear-cut set of recommendations for action, planning, and research. Of special interest is the chapter on the biological effects of oil itself and of oil treated with chemical dispersants.
From the contents: A- C. Brater and M. D. Murray: The effects of NSAIDs on the kidney A- G. Edwards and A. H. Weston: Latest developments in potassium channel modulator drugs A- M.R. Juchau and Y. Huang: Chemical teratogenesis in humans: Biochemical and molecular mechanisms A- S.P. Gupta: Studies on cardiovascular drugs A- G. Polak: Antifungal chemotherapy: An everlasting battle A- O. Valdenaire: New insights into the bioamine receptor family
Dunmore's War of 1774 was the culmination of a long series of disputes between settlers and Native Americans in western Virginia and Pennsylvania. In an effort to quell the increasingly violent Indian incursions, Virginia Governor John Murray, the Earl of Dunmore, carried on a successful retaliatory campaign known as "Dunmore's War." This book presents a history of that war through the use of primary documents selected from the mass of manuscript historical material in the famous Draper Collection at the Wisconsin Historical Society. Numerous footnotes throughout the volume provide a wealth of biographical information, as do the lists of muster rolls and biographies of field officers at the end of the book.