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Principles of Pharmacogenetics and Pharmacogenomics
This textbook presents the latest information on pharmacogenetics and pharmacogenomics for students, professionals and researchers.
Pharmacogenetics and Individualized Therapy
This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.
Pharmacogenetics
Drugs are administered to patients with the intention of achieving an expected therapeutic response. Yet drug therapy remains a medical art because of the wide variation in individual responses to standard drug doses. Pharmacogenetics emerged as a field aimed at identifying heritable factors that are predictive of individual variations in drug efficacy and toxicity from the dedicated work of a small group of investigators who in the 1950s began to enrich the discipline of pharmacology by integrating it with human genetics. Pharmacogenetics provides the experimental framework to understand variation in human reactions to drugs and other exogenous substances as a function of inborn human genet...
Pharmacogenetics
Pharmacogenetics is the study of the effects of individual genetics on drug responses. This book provides an overview of the current state of the pharmacological genetic aspects of these treatments. It discusses drugs with genetic information to support product labeling, clinical guidelines, or significant mechanical effects. Pharmacogenetic studies have also allowed us to better understand the pharmacology of medications used to treat neurologic and psychiatric disorders. This book also reviews the current state of the science and potential clinical utility of pharmacogenetic markers for these treatments. Furthermore, it highlights the in silico approach as a promising tool for further research on experimental pharmacology.
New Research on Pharmacogenetics
The terms pharmacogenomics and pharmacogenetics tend to be used interchangeably, and a precise, consensus definition of either remains elusive. Pharmacogenetics is generally regarded as the study of genetic variation that gives rise to differing response to drugs, while pharmacogenomics is the broader application of genomic technologies to new drug discovery and further characterization of older drugs. Pharmacogenetics considers one or at most a few genes of interest, while pharmacogenomics considers the entire genome. Much of current clinical interest is at the level of pharmacogenetics, involving variation in genes involved in drug metabolism with a particular emphasis on improving drug safety. This new book presents leading-edge research in this dynamic field.
10 Years of Pharmacogenetics and Pharmacogenomics
The Specialty Section “Pharmacogenetics and Pharmacogenomics” makes part of two different Journals: Frontiers in Pharmacology and Frontiers in Genetics. This Specialty Section focuses on the mechanisms by which genetic variations influence drug effects and adverse drug events, and cover basic research, clinical translation, applications in drug development and regulatory issues related to this field. Also, studies addressing the role of other factors such as epigenetics, phenotypic factors or drug-drug interactions on drug pharmacokinetics or pharmacodynamics are welcome. The editorial board is composed of 34 Associate Editors which, together with the Guest Associate Editors and the Reviewer Editors, constitute a team of nearly 340 leading experts in the field of Pharmacogenetics and Pharmacogenomics. This guarantees high quality in the reviewing process as well as short review times. A look back: 10 years of Frontiers in Pharmacogenetics & Pharmacogenomics (Continued in eBook)
Pharmacogenomics
Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.
Clinical Applications of Pharmacogenetics
The rapidly evolving field of Pharmacogenetics aims at identifying the genetic factors implicated in the inter-individual variation of drug response. These factors could enable patient sub-classification based on their treatment needs thus expediting drug development and promoting personalized, safer and more effective treatments. This book presents Pharmacogenetic examples from a broad spectrum of different drugs, for different diseases, which are representative of different stages of evaluation or application. It has been designed so as to serve both the unfamiliar reader through explanations of basic Pharmacogenetic concepts, the clinician with presentation of the latest developments and international guidelines, and the research scientist with examples of Pharmacogenetic applications, discussions on the limitations and an outlook on the new scientific trends in this field.
Pharmacogenetics: Opportunities and Challenges for Health Innovation
This book reviews how the emergence of pharmacogenetics will impact the efficiency of pharmaceutical R&D and improve healthcare decision making and clinical care. It discusses what policies need to change in order for the public to reap the benefits from advances in diagnostic genetic testing.
Pharmacogenetics
Genes are important modifiers of human response to drugs, hormones, and toxins. Patients and healthy individuals alike display significant differences in response and suffer adverse effects as a result of exposure to many therapeutic agents as well as occupational chemicals. This introductory text brings together laboratory methods and epidemiologic studies for defining the role of heredity in human drug response. This book will benefit graduate students in pharmacology, genetics, epidemiology, nursing, and public health, and will serve as a handy reference for pharmacists, epidemiologists, and physicians responsible for the delivery and administration of drugs.
