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Rise and Fall of Epithelial Phenotype
Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT). The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.
Epithelial-mesenchymal Transitions: New Advances in Development, Fibrosis and Cancer
This special issue represents a progression through signaling processes, development, fibrosis and cancer, illustrating common underlying mechanisms and highlighting the growing recognition of therapeutic possibilities. Novel molecular pathways are shown in the context of known regulators, and many articles offer specific insights into therapeutic targeting. Not surprisingly, several articles relate to the signaling pathways activated by the common anchor transforming growth factor (TGF)-beta in relation to epithelial-mesenchymal transition (EMT). A number of new mechanisms with therapeutic implications are described, specifically the interplay between the non-Smad PI3 kinase-Akt-mTOR axis and EMT-associated invasion in response to TGF-beta, the unexpected role of c-Abl in repressing TGF-beta1-induced EMT, the cooperativity between oncostatin M, hepatocyte growth factor and TGF-beta1 in lung carcinoma EMT, and the roles of dystroglycan and periostin in developmental EMT associated with gastrulation and palate fusion, respectively. Collectively, the issue presents the full spectrum of interest in EMT today.
In Situ Hybridization Protocols
The technique of in situ hybridization, in its various forms, has been used routinely in many laboratories for a number of years. In the post-genome era, gene arrays and proteomics have allowed us to identify hitherto unknown unrecognized pathways and mechanisms. However, rather than diminish the importance of in situ hybridization, the now widespread use of screening te- nologies has increased the need to temporally and spatially localize the dist- bution of mRNA expression. Our intention, in In Situ Hybridization Protocols is to provide ample inf- mation for novices planning to set up the in situ hybridization technique and use it in their laboratory for the first time, as well as giving u...
The NIH Record
None
Scientific Directory and Annual Bibliography
Presents the broad outline of NIH organizational structure, theprofessional staff, and their scientific and technical publications covering work done at NIH.
ETUDE DES MECANISMES INVASIFS DE COLONISATION DE L'EBAUCHE THYMIQUE PAR DES PRECURSEURS HEMATOPOIETIQUES CHEZ L'EMBRYON D'OISEAU
AU COURS DE L'EMBRYOGENESE, L'EBAUCHE THYMIQUE EST COLONISEE PAR DES CELLULES HEMATOPOIETIQUE PRECURSEURS. LEUR ACTIVATION PAR UN PEPTIDE ET, UN CONTACT DIRECT AVEC LA FIBRONECTINE ET LA LAMININE PRESENTES DANS L'ENVIRONNEMENT THYMIQUE OU LA MEMBRANE BASALE AMNIOTIQUE PARAIT REQUISE DANS CETTE MIGRATION
DNA and Cell Biology
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Cellular Adhesion in Development and Disease
Cell adhesion is a fundamental determinant of embryonic development and organogenesis. Cellular Adhesion in Development and Disease, volume 112 in Current Topics in Developmental Biology, comprehensively surveys current developments in understanding how adhesion systems affect organismal development. Topics covered include nectins, nectin-like molecules, and afadin in development; cadherin adhesion, signaling, and morphogenesis; endothelial cell junctions; epidermal development and barrier formation; and more. This book surveys current understanding of how adhesion systems affect organismal development
