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Six decades after the serendipitous discovery of chlorpromazine as an antipsychotic and four decades after the launch of clozapine, the first atypical or second generation antipsychotic, psychopharmacology has arrived at an important crossroad. It is clear that pharmacological research and pharmaceutical development must now focus on complementary or even alternative mechanisms of action to address unmet medical needs, i.e. poorly treated domains of schizophrenia, improved acceptance by patients, better adherence to medication, safety in psychoses in demented patients, and avoiding cardiac and metabolic adverse effects. The first completely novel mechanisms evolving from our insights into th...
Psychiatrist R.L. Kapur gets curious about a possible connection between psychology and asceticism. Intrigued by Indian spiritual traditions and mindful of the number of people in India who visit ascetics to treat psychological problems like schizophrenia, Kapur takes a year's sabbatical to learn yoga from Patanjali's Yoga Sutras, keeping a meticulous diary of the effects of the exercise. Armed with the experience he climbs the rocky slopes of the Himalayas to meet and interview ascetics from different sects of Hinduism. He comes across a varied group—philosophers, intellectuals, artists, visionaries; some believed they were destined to become sadhus, others were prompted by circumstances.
This two-volume textbook provides a comprehensive review of both adult and pediatric gastrointestinal, hepatobiliary and pancreatic pathology. The 1st volume is dedicated to gastrointestinal tract pathology. The second volume of this book covers liver, biliary system, and pancreatic pathology. This book covers each aspect of gastrointestinal tract pathology in detail, including clinical presentation, endoscopic appearance, disease pathogenesis, gross and microscopic details of each lesion. Ancillary diagnostic methods, molecular subtypes, and prognostic workup have been detailed adequately. The book also covers diseases relevant to South-East Asia, in addition to diseases prevalent worldwide...
Memory, Attention, and Aging is a collection of some of the most influential journal articles previously published by Fergus Craik and his collaborators, with new introductory material unifying the research of this noted cognitive psychologist. The reprinted articles are grouped into six sections reflecting Craik’s various research interests across his career. The first section on short-term memory focuses on research concerns Craik uncovered in the 1970s, but are still valid today. They comprise theoretical suggestions and data on the nature of STM, including the notion that working memory may be defined as attention paid to features of items held in conscious awareness. The second sectio...
This book constitutes the refereed proceedings of the Second International Conference on Formal Methods in Computer-Aided Design, FMCAD '98, held in Palo Alto, California, USA, in November 1998. The 27 revised full papers presented were carefully reviewed and selected from a total of 55 submissions. Also included are four tools papers and four invited contributions. The papers present the state of the art in formal verification methods for digital circuits and systems, including processors, custom VLSI circuits, microcode, and reactive software. From the methodological point of view, binary decision diagrams, model checking, symbolic reasoning, symbolic simulation, and abstraction methods are covered.
The report is part of a series of background papers prepared within the context of the development of the the Near East and North Africa Region of the State of Land and Water Resources for Food and Agriculture (SOLAW) in the Near East and North Africa Region. The paper reflects on the status of soil degradation and fertility loss, the drivers that put pressure on soils and land in the region, the responses to address the pressing issues leveraging existing technical knowledge, as well as tools for assessment and monitoring.
The Oxford Handbook of Nonsuicidal Self-Injury is a compendium of up-to-date research and knowledge of topics germane to the field of nonsuicidal self-injury (NSSI). Edited by renowned scholars Elizabeth E. Lloyd-Richardson, Imke Baetens, and Janis L. Whitlock, the handbook brings together cutting-edge research from a group of internationally distinguished scholars. It covers a wide array of topics including epidemiology, function, neurophysiological processes, lived experience, and intervention and prevention approaches. This comprehensive text will serve as a go-to guide for scholars, clinicians, and anyone with interest in understanding, treating, and preventing self-injury.