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Chaos
As featured on The Joe Rogan Experience ______________________________ A journalist's twenty-year obsession with the Manson murders leads to shocking new conspiracy theories about the FBI's involvement in this fascinating re-evaluation of one of the most infamous cases in American history. Twenty years ago, reporting for a routine magazine piece about the infamous Manson murders, journalist Tom O'Neill didn't expect to find anything new. But the discovery of horrifying new evidence kick-started an obsession and his life's work. What had he unearthed and what did it mean: why was there surveillance by intelligence agents? Why did the police make these particular mistakes and why did Tom's gre...
Menopause for the MRCOG and Beyond
This book is a guide to perimenopausal medicine for Part 2 MRCOG examination candidates and all healthcare professionals.
Nanoscale Quantum Optics
With the launch of the Quantum Technology Flagship Programme by the European Commission, developments in the realization of new technologies based on quantum physics have been recognized as a priority. These are important for cryptographic techniques for telecommunications security, new computing hardware that can solve problems so far inaccessible even to the latest generation of supercomputers, and precision standards and sensors with important applications ranging from materials science to medical diagnostics. This book presents a collection of lectures from the International School of Physics Enrico Fermi on Nanoscale Quantum Optics, held in Varenna, Italy, from 23 – 28 July 2018. The ...
Development of Therapeutic Agents Handbook
A comprehensive look at current drug discovery and development methods—and the roadmap for the future Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and limitations that need to be considered in the formulation of therapeutic agents across a range of therapeutic fields. Both a reference and a call to action for the pharmaceutical industry, Development of Therapeutic Agent...
Oxidative Stress and Neurodegenerative Disorders
Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.* Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems
Essentials of Menopause Management
Removing the shroud of complexity that had engulfed the field of menopause research and management for more than a decade, this unique, case-based resource discusses a range of topics relevant to the reproductive health of the aging female. The opening section includes chapters covering the symptomatology, epidemiology and impact of the menopausal burden, and reviews in depth the most current evidence on the efficacy, risks and benefits of pharmacological and alternative therapies. Utilizing vibrant case material, the second section details common symptoms of menopause and an individualized approach to management, such as sleep loss, skeletal fragility, sexual dysfunction, hirsutism and alop...
Comprehensive Toxicology
An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version
Stroke
Stroke is a leading cause of death and the major cause of long-term, physical, psychological and social disability in the elderly around the world. Knowing and treating the most common risk factors for stroke such as hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, and obesity may reduce the occurrence of stroke sub-stantially. In the last decades, there has been tremendous progress in the development of noninvasive diagnostic techniques like ultrasound MRI, CT angiography, CT perfusion, as well as new effective therapeutic strategies for acute ischemic stroke which established vascular neurology as one of the most progressive fields in medicine. This publication provides the reader with the most recent updated advanced knowl-edge on the practical clinical approach to stroke medicine. It covers essential and practical information on the pathophysiology and epidemiology of stroke, new diagnostic techniques which allow for better diagnosis and identification of various subtypes of stroke, and new therapeutic strategies for acute stroke and transient ischemic attack.
Obesity and Cancer
This book provides a comprehensive and up-to-date review of the relationship between obesity and cancer. It opens with a global perspective on obesity and cancer incidence, followed by in-depth discussions of those cancers for which we have sufficient evidence of a causal relationship with obesity. It addresses topics such as the effects of obesity on cancer incidence and cancer survival, the effects of weight gain and weight loss in adulthood on cancer risk, the effects of childhood and adolescent obesity, and the role of body fat distribution in cancer risk. Individual chapters discuss potential pathways for the observed associations and explore possible mechanisms from both an epidemiological and an experimental perspective. It concludes with a population perspective on the cancer risk that is attributable to obesity and is thus potentially avoidable. This book is of particular value to researchers and epidemiologists and is also of interest to public health workers and clinicians.
