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The complex phenotype of Diabetic Cardiomyopathy: clinical indicators and novel treatment targets
  • Language: en
  • Pages: 106

The complex phenotype of Diabetic Cardiomyopathy: clinical indicators and novel treatment targets

Diabetic cardiomyopathy is a clinical condition of heart dysfunction that develops in the absence of hypertension and coronary atherosclerosis in diabetic patients. The main characteristics of diabetic cardiomyopathy are myocardial fibrosis, cardiac stiffness, left ventricular hypertrophy and decreased left ventricular compliance. This eventually progresses to clinical heart failure with reduced ejection fraction. To detect changes in cardiac structure and function, such as fibrosis, several noninvasive techniques have been used. These include echocardiography, cinematic magnetic resonance imaging, and computed tomography. From a mechanistic perspective; oxidative stress, inflammation, enhan...

Molecular Mechanisms and Signaling in Endothelial Cell Biology and Vascular Heterogeneity
  • Language: en
  • Pages: 332
Mitochondrial Physiology and Vegetal Molecules
  • Language: en
  • Pages: 808

Mitochondrial Physiology and Vegetal Molecules

Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health provides a comprehensive overview of mitochondrial physiology throughout the human life span, as well as the effect of molecules of vegetal origin on mitochondrial health. The editor has lined up a team of worldwide experts to cover the most exciting and high-impact advancements of research in this area. This book is structured into two parts that provide a balance of both foundational and applied content. Part I provides an overview of mitochondrial physiology including its structure, dynamics, biogenesis, membranes, DNA transcription, and translation in the mitochondria. Part ...

Novel Targets for Chronic Inflammatory Diseases: Focus On Therapeutic Drugs and Natural Compounds, volume II
  • Language: en
  • Pages: 139

Novel Targets for Chronic Inflammatory Diseases: Focus On Therapeutic Drugs and Natural Compounds, volume II

This Research Topic is part of a series with: Novel Targets for Chronic Inflammatory Diseases: Focus On Therapeutic Drugs and Natural Compounds Chronic inflammation is a component of many disease conditions that affect a large group of individuals worldwide, which is characterized by persistent, low-grade inflammation and is increased in the aging population. It occurs when an initiating stimulus is not removed or if the resolution process is disrupted, resulting in a state of low-grade inflammation. It is acknowledged that chronic inflammatory diseases are involved in cardiovascular diseases, endocrine disease, neurodegenerative disease, hepatic disease, pulmonary disease, gastrointestinal ...

Polyphenols in Human Health and Disease
  • Language: en
  • Pages: 1504

Polyphenols in Human Health and Disease

Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more. - Explores neuronal protection by polyphenol metabolites and their application to medical care - Defines modulation of enzyme actions to help researchers see and study polyphenols' mechanisms of action, leading to clinical applications - Includes insights on polyphenols in brain and neurological functions to apply them to the wide range of aging diseases

Medicinal Plant Research in Africa
  • Language: en
  • Pages: 917

Medicinal Plant Research in Africa

  • Type: Book
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  • Published: 2013-06-19
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  • Publisher: Newnes

The pharmacopoeias of most African countries are available and contain an impressive number of medicinal plants used for various therapeutic purposes. Many African scholars have distinguished themselves in the fields of organic chemistry, pharmacology, and pharmacognosy and other areas related to the study of plant medicinal plants. However, until now, there is no global standard book on the nature and specificity of chemicals isolated in African medicinal plants, as well as a book bringing together and discussing the main bioactive metabolites of these plants. This book explores the essence of natural substances from African medicinal plants and their pharmacological potential. In light of possible academic use, this book also scans the bulk of African medicinal plants extract having promising pharmacological activities. - The book contains data of biologically active plants of Africa, plant occurring compounds and synthesis pathways of secondary metabolites - This book explores the essence of natural substances from African medicinal plants and their pharmacological potential - The authors are world reknowned African Scientists

Nutritional Epigenomics
  • Language: en
  • Pages: 480

Nutritional Epigenomics

Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition's role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet's role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity a...

Autophagy in Health and Disease
  • Language: en
  • Pages: 241

Autophagy in Health and Disease

Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. - Discusses current understanding of the roles of autophagy in health and disease - Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes

Growth Control in Woody Plants
  • Language: en
  • Pages: 658

Growth Control in Woody Plants

  • Type: Book
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  • Published: 1997-01-21
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  • Publisher: Elsevier

The processes and mechanisms that control the growth of woody plants are of crucial importance for both economic and biological reasons. The comprehensive coverage of Growth Control in Woody Plants includes discussion of the growth controlling factors in both reproductive structures (flowers, fruit, seeds, pollen, etc.) and vegetative organs (stems, branches, leaves, and roots). Other major topics covered include seed germination, seedling growth, physiological and environmental regulation of growth, cultural practices, and biotechnology.This comprehensive treatment of the many factors that control the growth of woody plants can serve both as a valuable text and as a frequently used reference.* Includes comprehensive representation of a broad subject* Provides thorough bibliographic coverage * Well illustrated* Serves as a vital companion to Physiology of Woody Plants, Second Edition