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Microglia
This book presents a comprehensive toolkit of versatile techniques for studying microglia under different experimental settings along with a brief summary of knowledge, accumulated in microglial research over the last decades. Beginning with recently discovered roles of microglia in health and disease, the volume continues by covering in vitro analyses of microglia, in vivo studies, and “omics” analyses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Microglia: Methods and Protocols serves as a vital guide to these important cells and an inspiration for scientists interested in expanding our knowledge of their role in the nervous system.
Microglia in Health and Disease
These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set mic...
Theoretical Neuroscience
Theoretical neuroscience provides a quantitative basis for describing what nervous systems do, determining how they function, and uncovering the general principles by which they operate. This text introduces the basic mathematical and computational methods of theoretical neuroscience and presents applications in a variety of areas including vision, sensory-motor integration, development, learning, and memory. The book is divided into three parts. Part I discusses the relationship between sensory stimuli and neural responses, focusing on the representation of information by the spiking activity of neurons. Part II discusses the modeling of neurons and neural circuits on the basis of cellular and synaptic biophysics. Part III analyzes the role of plasticity in development and learning. An appendix covers the mathematical methods used, and exercises are available on the book's Web site.
Body and Spirit in the Middle Ages
A crucial question throughout the Middle Ages, the relationship between body and spirit cannot be understood without an interdisciplinary approach – combining literature, philosophy and medicine. Gathering contributions by leading international scholars from these disciplines, the collected volume explores themes such as lovesickness, the five senses, the role of memory and passions, in order to shed new light on the complex nature of the medieval Self.
Information Theory in Neuroscience
As the ultimate information processing device, the brain naturally lends itself to being studied with information theory. The application of information theory to neuroscience has spurred the development of principled theories of brain function, and has led to advances in the study of consciousness, as well as to the development of analytical techniques to crack the neural code—that is, to unveil the language used by neurons to encode and process information. In particular, advances in experimental techniques enabling the precise recording and manipulation of neural activity on a large scale now enable for the first time the precise formulation and the quantitative testing of hypotheses about how the brain encodes and transmits the information used for specific functions across areas. This Special Issue presents twelve original contributions on novel approaches in neuroscience using information theory, and on the development of new information theoretic results inspired by problems in neuroscience.
Paratexts
Paratexts are those liminal devices and conventions, both within and outside the book, that form part of the complex mediation between book, author, publisher and reader: titles, forewords, epigraphs and publishers' jacket copy are part of a book's private and public history. In this first English translation of Paratexts, Gérard Genette shows how the special pragmatic status of paratextual declaration requires a carefully calibrated analysis of their illocutionary force. With clarity, precision and an extraordinary range of reference, Paratexts constitutes an encyclopedic survey of the customs and institutions as revealed in the borderlands of the text. Genette presents a global view of these liminal mediations and the logic of their relation to the reading public by studying each element as a literary function. Richard Macksey's foreword describes how the poetics of paratexts interact with more general questions of literature as a cultural institution, and situates Gennet's work in contemporary literary theory.
Nanotechnology in Catalysis 3
"Based on the first and second symposia on Nanotechnology in Catalysis which were held in spring 2001 at the ACS 221st National Meeting in San Diego, CA, and in fall 2002 at the ACS 224th National Meeting in Boston, MA."--Pref.
