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Prognostic Relevance of Tumor-infiltrating Lymphocytes and Immune Checkpoints in Pediatric Medulloblastoma
Abstract: Pediatric medulloblastomas are the most frequently diagnosed embryonal tumors of the central nervous system. Current therapies cause severe neurological and cognitive side effects including secondary malignancies. Cellular immunotherapy might be key to improve survival and to avoid morbidity. Efficient killing of tumor cells using immunotherapy requires to overcome cancer-associated strategies to evade cytotoxic immune responses. Here, we examined the immune response and immune evasion strategies in pediatric medulloblastomas. Cytotoxic T-cells, infiltrating medulloblastomas with variable activation status, showed no correlation with overall survival of the patients. We found limit...
Animal Influenza
Animal Influenza, Second Edition is a comprehensive text on animal influenza. Organized by species, coverage includes avian, swine, equine and mammals, with each section including data on influenza viruses, the infection and disease they cause, and strategies used in control. Covers the full range of topics within avian, swine, equine and mammalian influenzas in one comprehensive and authoritative text Provides a summarization of peer-reviewed and empirical data on influenza viruses, the infection, and diseases they cause Discusses strategies used in control of the disease Leading experts are drawn together to provide an international and multi-disciplinary perspective Fuses latest developments in basic scientific research with practical guidance on management of the disease
Myocardial Imaging
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Implementing High-Quality Primary Care
High-quality primary care is the foundation of the health care system. It provides continuous, person-centered, relationship-based care that considers the needs and preferences of individuals, families, and communities. Without access to high-quality primary care, minor health problems can spiral into chronic disease, chronic disease management becomes difficult and uncoordinated, visits to emergency departments increase, preventive care lags, and health care spending soars to unsustainable levels. Unequal access to primary care remains a concern, and the COVID-19 pandemic amplified pervasive economic, mental health, and social health disparities that ubiquitous, high-quality primary care mi...
International Review of Research in Mental Retardation
International Review of Research in Developmental Disabilities is an ongoing scholarly look at research into the causes, effects, classification systems, syndromes, etc. of mental retardation. This thematic volume, "Health Issues in Down Syndrome," will cover health issues for individuals across the life span. With the life expectancy of individuals now reaching 60 years or more, it has transformed from an acute condition with a short life span to a chronic condition that needs to be managed over a close to normal life span. The extra chromosome 21 that defines most cases of Down syndrome affects the functioning of many biological processes and organ systems. The cascade of events triggered by the extra chromosome 21 creates a complex set of medical conditions needing to managed over the life span. The ability to manage these conditions has led to an improvement in longevity and quality of life for individuals with Down syndrome. - Provides the most recent scholarly research in the study of health issues in Down syndrome - A vast range of perspectives is offered, and many topics are covered - An excellent resource for academic researchers
Society Of The Spectacle
The Das Kapital of the 20th century,Society of the Spectacle is an essential text, and the main theoretical work of the Situationists. Few works of political and cultural theory have been as enduringly provocative. From its publication amid the social upheavals of the 1960's, in particular the May 1968 uprisings in France, up to the present day, with global capitalism seemingly staggering around in it’s Zombie end-phase, the volatile theses of this book have decisively transformed debates on the shape of modernity, capitalism, and everyday life in the late 20th century. This ‘Red and Black’ translation from 1977 is Introduced by Notting Hill armchair insurrectionary Tom Vague with a galloping time line and pop-situ verve, and given a more analytical over view by young upstart thinker Sam Cooper.
Drugs and the Liver
This practical guide covers background information on liver function, the principles of drug use in liver disease and includes a section of worked examples of commonly asked questions. It will be invaluable to clinical pharmacists and anyone making medicine choices in patients with liver impairment.
Managing and Transforming Water Conflicts
What is the one thing that no one can do without? Water. Where water crosses boundaries – be they economic, legal, political or cultural – the stage is set for disputes between different users trying to safeguard access to a vital resource, while protecting the natural environment. Without strategies to anticipate, address, and mediate between competing users, intractable water conflicts are likely to become more frequent, more intense, and more disruptive around the world. In this book, Delli Priscoli and Wolf investigate the dynamics of water conflict and conflict resolution, from the local to the international. They explore the inexorable links between three facets of conflict management and transformation: Alternative Dispute Resolution (ADR), public participation, and institutional capacity. This practical guide will be invaluable to water management professionals, as well as to researchers and students in engineering, economics, geography, geology, and political science who are involved in any aspects of water management.
Multilingual Healthcare
This volume is the first to address multilingual healthcare communication around the globe and focuses on institutional, social and linguistic challenges and resources of the healthcare industry. It comprises studies from Canada, Australia, South Africa, Greenland, Italy, Germany, Switzerland and Belgium, and aims to introduce new paths of communicative and methodological agendas, casting a critical view on current linguistic practices in healthcare, nursing and medical interactions. With increased personal mobility in a global society, the need for multilingual staff is on the rise in medical institutions and healthcare organisations, and communicative competencies and practices involving d...
Beyond Being Koelies and Kantráki
This book traces the self-positioning of Hindostani people in the face of British and Dutch colonial practices. Originally from India and shipped to the Dutch colony of Suriname after the abolition of slavery, the Hindostani served as contract labourers to keep the plantation system afloat from 1873. Central to the book is the perspective of the Hindostani themselves. We travel alongside the Hindostani from the moment they were recruited and their movement through the depots awaiting shipment, their travel experiences, their arrival in Suriname, relocation to plantations, and their dispersal following the end of their contracts, either as city workers, or farmers. All along, the book poses the question of identification: how did Hindostani make sense of themselves, their fellow Hindostani, and Surinamese society? Stereotyped images make way for insight in lived experience of lower and higher caste, Hindus and Muslims, men and women.
