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Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations
PAAMS, the International Conference on Practical Applications of Agents and Multi-Agent Systems is an international yearly forum to present, to discuss, and to disseminate the latest developments and the most important outcomes related to real-world applications. It provides a unique opportunity to bring multi-disciplinary experts, academics and practitioners together to exchange their ex-perience in the development of Agents and Multi-Agent Systems. This volume presents the papers that have been accepted for the 2010 edition in the Special Sessions and Workshops. PAAMS'10 Special Sessions and Workshops are a very useful tool in order to complement the regular program with new or emerging topics of particular interest to the participating community. Special Sessions and Workshops that emphasize on multi-disciplinary and transversal aspects, as well as cutting-edge topics were especially encouraged and welcomed.
As almost no other technology, embedded systems is an essential element of many innovations in automotive engineering. New functions and improvements of already existing functions, as well as the compliance with traffic regulations and customer requirements, have only become possible by the increasing use of electronic systems, especially in the fields of driving, safety, reliability, and functionality. Along with the functionalities that increase in number and have to cooperate, the complexity of the entire system will increase. Synergy effects resulting from distributed application functionalities via several electronic control devies, exchanging information through the network brings abou...
The IFIP TC-10 Working Conference on Distributed and Parallel Embedded Systems (DIPES 2004) brings together experts from industry and academia to discuss recent developments in this important and growing field in the splendid city of Toulouse, France. The ever decreasing price/performance ratio of microcontrollers makes it economically attractive to replace more and more conventional mechanical or electronic control systems within many products by embedded real-time computer systems. An embedded real-time computer system is always part of a well-specified larger system, which we call an intelligent product. Although most intelligent products start out as stand-alone units, many of them are required to interact with other systems at a later stage. At present, many industries are in the middle of this transition from stand-alone products to networked embedded systems. This transition requires reflection and architecting: The complexity of the evolving distributed artifact can only be controlled, if careful planning and principled design methods replace the - hoc engineering of the first version of many standalone embedded products.
Table of Contents First block Physical Activity Warm-Up Stretching Exercises Physical Fitness and Basic Physical Skills Strength Stamina Speed Flexibility Second block Motor Skills: Coordinated Movement Balance Coordination Third block The Human Body: Anatomical and Physiological Bases Body Posturel Nutrition and Training Relaxation First Aid Designing a Training Programme Fourth block History of Physical Education Physical Education and Sports The Olympic Movement Glossary
Pedro Feitoza traces the history of Protestantism in Brazil through an analysis of the production and circulation of evangelical texts. Examining a wide range of periodicals, tracts, correspondence, and other archival records and delving into the ideology of religious thinkers and evangelists of the time, Feitoza considers how Protestant veneration of the written word led to a complex infrastructure for the distribution of religious texts and the fostering of literacy in Brazil in the late 19th and early 20th centuries.
Roberto Burle Marx was one of the most influential landscape and garden designers of the 20th century. This book presents 26 projects in plans, photographs and Burle Marx's own paintings. The introduction considers his life, ideas and work.