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Pharmacology of Antimuscarinic Agents
The theoretical and practical significance of antimuscarinic drugs is more obvious today than ever before. Antimuscarinics have helped to explore the pathomechanisms of of Alzheimer's disease, and to treat the symptoms of Parkinson's, cardiovascular problems, gastrointestinal diseases, and even nerve gas poisoning. No other drug class can claim as long a history with so many therapeutic applications, yet the most significant developments in this broad chapter of pharmacology come from the discovery of different muscarinic receptor sites in the peripheral and central nervous system and from the availability of many new selective agents, notably antagonists, for these different receptor types. Pharmacology of Antimuscarinic Agents, written by an expert in anesthesiology and drug research, focuses on the basic principles of antimuscarinic drugs, their therapeutic value, how they work, and what versions are now available in the U.S. and abroad. This is the first time in decades an author has reviewed historical and current literature to present a comprehensive, standard reference on the antimuscarinic family.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Placental Toxicology
Placental Toxicology examines placental transfer and toxicology of drugs and environmental agents to placenta, as well as to fetus. For the first time in a single volume, placental and fetal consequences of exposure of pregnant women to drugs, environmental chemicals, and infections, such as HIV, are discussed. Topics include: The art of in
Preclinical and Clinical Modulation of Anticancer Drugs
Preclinical and Clinical Modulation of Anticancer Drugs focuses on the theoretical and practical approaches to designing and enacting modulation principles. Each class of anticancer drug and the different types of modulators used within each drug class are discussed within individual chapters. The molecular and biochemical rationale for the use of specific modulators is discussed in detail, and preclinical and clinical implications of the data are integrated into each chapter. Mechanisms of drug resistance and the reasons behind circumventing the resistant phenotype are covered. The book will interest cancer chemotherapists, pharmacologists, oncologists, biochemists, and experimental therapeutics researchers, in addition to students studying the principles of drug discovery and protocol design.
Beneficial and Toxic Effects of Aspirin
Recently, aspirin has been found to be associated with a decreased risk of heart disease and other newly found health benefits. However, it produces allergy-like and toxic effects in many individuals. Beneficial and Toxic Effects of Aspirin reviews in a single volume the benefits of aspirin and its adverse effects. A panel of experts has been gathered to contribute to this work, providing a balanced view of multiple topics. Contributors to this volume include outstanding allergists who describe bronchial and skin sensitivity to aspirin as well as prevention and treatment. Other experts cover:
Antibody Therapeutics
Published in 1997: Antibody Therapeutics is a comprehensive evaluation of progress toward using humanized antibodies as a new generation of therapeutics. The humanized antibodies that have led the way in product approval are discussed as case studies, offering an insight into the preclinical and clinical data acquired during the regulatory approval process. Leading experts offer their findings as examples of what works and what does not, saving you time and making your research more cost effective. This book is essential reading for researchers, clinicians, development and regulatory staff in pharmaceutical and biotechnology companies, and hospital staff, including policy and decision makers. It also provides postgraduate and medical students with an authoritative overview of the field.
Pharmacological Regulation of Gene Expression in the CNS Towards an Understanding of Basal Ganglial Functions (1996)
This book focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. It is an excellent review of experimental data on interactions between neuronal systems at systemic, cellular, and molecular levels. Each of the chapters, written by the world's leading scientists, provides an understanding of anatomy, neurochemistry, and cellular and molecular effects. Such an understanding sheds light on the pathophysiology of central disorders involving the basal ganglia and leads to new approaches for the treatment of diseases such as Parkinson's disease and schizophrenia, and also addictions to psychostimulants such as cocaine and amphetamines.
