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Drugs for Relapse Prevention of Alcoholism
Alcoholism is a pathological behavioural syndrome, characterised by comp- sive alcohol use, craving and relapses, even recurring after many years of abstinence. It is suggested that chronic alcohol abuse leads to persistent changes within several neurochemical pathways in the brain and furthermore that an imprinted drug and addiction memory may scarcely be extinguished. Hence, the question arises as to whether there ought to be a reasonable hope that pharmacological drugs will be developed that interfere with an addiction memory, and as a result, finally lead to a cure? In this book, leading preclinical and clinical experts in the field of alcohol relapse prevention strive to furnish an answ...
Baclofen in the Treatment of Alcohol Use Disorder
This is a collection on use of the GABA-B agonist Baclofen in the use of alcohol use disorder. The articles center around efficacy of Baclofen ranging from acute withdrawal to maintenance of abstinence, address the issue of dosing and indications and variation of Baclofen use worldwide.
Brief Interventions for Risky Drinkers
Alcohol is the sixth leading risk factor for disability and premature death all over the world, and one of the leading causes of premature mortality in western societies; it is a leading risk factor for death in young and middle-age males. Heavy drinking accounts for about two thirds of the burden of disease attributable to alcohol. In the early 1980s, screening and brief interventions (SBI) in primary health care settings were proposed as effective strategies to identify risky drinkers and to help them reduce their drinking. Since then, a growing body of evidence, including several meta-analysis and Cochrane reviews, has shown the efficacy and effectiveness of SBI in primary health settings...
The End of Alcohol Addiction
The worldwide burden of alcoholism on affected individuals, their families, and society is enormous. People with alcohol use disorders tend to miss work, get into problems with the law, have financial difficulties, and alienate family and friends. Alcoholism also contributes to health problems such as heart disease, stroke, liver disease, brain damage, pancreatitis, and cancer as well as societal problems such as suicide, domestic violence, and accidents. Some medications help some patients with alcohol addiction, but no drug treatment has been shown to be effective in ending alcohol addiction. One drug, however, has shown promise. Baclofen, which is given for the treatment of multiple scler...
Basic and Clinical Science of Mental and Addictive Disorders
This is the most comprehensive update of basic and clinical information available on mental, addictive and various neurological disorders. Virtually every basic and clinical scientific methodology that is relevant to our understanding and management of brain-related diseases is included in this volume. Readers will find up-to-the-minute studies in functional brain imaging, including MRI and EEG/ERP mapping, the latest application of molecular biology and genetics to solve clinical problems, as well as recent findings on schizophrenia, Alzheimer's disease, drug addiction and alcoholism, suicide and mood disorders. A unique feature of this publication are the nine chapters which examine chroni...
When the Servant Becomes the Master
The definitive guide to all things related to addiction and its treatments—newly revised. The updated and revised second edition is a must-read for anyone struggling with addiction, their families, and the professionals who desire to know more about this baffling disease. Jason Powers, MD, approaches addiction from a variety of different angles, clearly and carefully attacking myths and misinformation, and bringing the reader up to date with the most current scientific and popular literature on addiction. Dr. Powers illuminates the entire spectrum of addiction-related topics, from neuroscience to treatment options, and guides the reader through the extensive material and to a more humane y...
Handbook of Psychiatric Genetics
Psychiatric genetics is an exciting new discipline that explores how our minds and behavior are influenced by our genes. Increased interest in this area of medical genetics has been sparked by advances in molecular genetic techniques, the genome project, the neurosciences, the role of genes in somatic diseases, and the linking of specific genes with complex mental disorders. This Handbook is the definitive resource on this complex, and sometimes controversial, new field.
The End of My Addiction
What if you there were a cure for addiction--a medication that eradicates the need for a fix? This is the story of Olivier Ameisen, a brilliant physician and cardiologist who developed a profound addiction to alcohol. He broke bones with no memory of falling and nearly lost his kidneys. He gave up his flourishing practice and invested himself in Alcoholics Anonymous and, later, rehab. Nothing worked. So he took his treatment into his own hands. Searching for a cure, he discovered baclofen, a muscle relaxant that had proven effective in curing rats addicted to every substance from nicotine and alcohol to cocaine and heroin. Ameisen prescribed himself the drug and, over a two-year period, experimented with the dosage until he reached a level high enough to leave him free of any craving for alcohol. This is both a memoir of Ameisen's own struggle and a groundbreaking call to action.--From publisher description.
GABAB Receptor
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The End Of My Addiction
Dr Olivier Ameisen was a brilliant cardiologist and running his own successful practice when he developed a profound addiction to alcohol. Fearing for his life, he immersed himself in AA, rehab and therapy. Nothing worked. So he did the only thing he could; he took his treatment into his own hands. Searching for a cure for his deadly disease, he happened upon baclofen, a muscle relaxant that had been used safely for years as a treatment for various types of muscle spasticity, but had more recently shown promising results in studies with laboratory animals addicted to a wide variety of substances. Dr Ameisen prescribed himself the drug and experimented with increasingly higher doses until he finally reached a level high enough to leave him free of any craving for alcohol. That was more than six years ago. Baclofen, as prescribed under a doctor's care, could possibly help many addicts. But as long as the medical and research establishments ignore a cure for one of the most deadly diseases in the world, we won't be able to understand baclofen's full potential. This book is a plea for research that can rescue millions from the scourge of addiction.
