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The worldwide burden of alcoholism on affected individuals, their families, and society is enormous. People with alcohol use disorders tend to miss work, get into problems with the law, have financial difficulties, and alienate family and friends. Alcoholism also contributes to health problems such as heart disease, stroke, liver disease, brain damage, pancreatitis, and cancer as well as societal problems such as suicide, domestic violence, and accidents. Some medications help some patients with alcohol addiction, but no drug treatment has been shown to be effective in ending alcohol addiction. One drug, however, has shown promise. Baclofen, which is given for the treatment of multiple scler...
This is a collection on use of the GABA-B agonist Baclofen in the use of alcohol use disorder. The articles center around efficacy of Baclofen ranging from acute withdrawal to maintenance of abstinence, address the issue of dosing and indications and variation of Baclofen use worldwide.
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Dr Olivier Ameisen was a brilliant cardiologist and running his own successful practice when he developed a profound addiction to alcohol. Fearing for his life, he immersed himself in AA, rehab and therapy. Nothing worked. So he did the only thing he could; he took his treatment into his own hands. Searching for a cure for his deadly disease, he happened upon baclofen, a muscle relaxant that had been used safely for years as a treatment for various types of muscle spasticity, but had more recently shown promising results in studies with laboratory animals addicted to a wide variety of substances. Dr Ameisen prescribed himself the drug and experimented with increasingly higher doses until he finally reached a level high enough to leave him free of any craving for alcohol. That was more than six years ago. Baclofen, as prescribed under a doctor's care, could possibly help many addicts. But as long as the medical and research establishments ignore a cure for one of the most deadly diseases in the world, we won't be able to understand baclofen's full potential. This book is a plea for research that can rescue millions from the scourge of addiction.
Audit is an essential activity for all psychiatrists. Involvement in audit must be evidenced by consultants for revalidation and by trainees in their Annual Review of Competence Progression (ARCP). This book will therefore be relevant for psychiatrists of all grades. It aims to help ease the audit process by offering tried and tested recipes for conducting audits in clinical services. All the audits in this book have been undertaken by the authors and it therefore provides useful practical advice for carrying out the audits in day-to-day practice.
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Dr. Levy has secured the field’s top experts to offer the latest clinical reviews on cholestatic liver disease. The issue will include articles devoted to The Gut-Liver Axis; Update on Genetics in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis; New thoughts on IgG4 Associated Cholangitis; Cancer Risk and Surveillance in PSC; Novel Therapies for PBC; and Liver transplantation for Cholestatic Liver Diseases, to name a few. Dr. Levy’s issue will be the most current authority on cholestatic liver disease.