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Targeting Epigenetics in Inflammatory Lung Diseases
This book discusses the role of epigenetics in pathogenesis of different pulmonary diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary tuberculosis, idiopathic pulmonary fibrosis and pulmonary infections. It also explores post-translational modifications in DNA and histones for improving the understanding of lung diseases. This book helps in understanding the epigenetic mechanisms towards the development of novel diagnostic and therapeutic approaches. Further, the book provides insight into the underlying molecular mechanisms involved in the epigenetic regulation of inflammation, which may have novel implications in designing small molecule inhibitors that target the epigenetic machinery for the effective treatment of a variety of inflammation‐related diseases. This book is a valuable resource for academics, research and industry professionals working in respiratory biology.
Lung Transplantation
This book details all aspects of lung transplantation and equips the general pulmonologist/physician with the necessary tools and knowledge to assist patients with the preparation for and care post lung transplantation. Written by global experts, chapters present general principles and history; indications and eligibility for lung transplantation, including screening for COPD, cystic fibrosis, scleroderma, Idiopathic pulmonary fibrosis (IPF) and idiopathic pulmonary arterial hypertension; approach to and complications of lung transplantation, such as prognostic markers, radiological approach, and immunology and rejection; and medical and surgical guidelines for lung transplantation. The goal...
Pulmonary Vascular Disorders
"Pulmonary vascular disorders are a complex and fascinating group of diseases. The aim of this book is to exhaustively review the genetics, physiology, diagnosis, management, and treatment of pulmonary vascular disorders with the purpose of helping general physicians and specialists in internal medicine, cardiology, pneumology, immunology, rheumatology, and hematology to identify and assess patients with vascular pulmonary disorders. Special emphasis has been placed upon pulmonary hypertension, pulmonary fibrosis, and pulmonary embolism as well as on pulmonary vascular involvement in immune-mediated diseases, chronic obstructive and advanced pulmonary disease, and sleep apnea. Additional topics that are covered in this book include pulmonary vascular injury occurring in alpha-1 antitrypsin deficiency, congenital heart disease and pregnancy. The text is supported by figures and tables to help the reader understand mechanisms of pulmonary vascular disorders in different clinical settings"--
Interstitial Lung Disease
Interstitial lung diseases are a diverse group of acute and chronic pulmonary disorders characterized by a variable amount of inflammation and/or fibrosis. In Interstitial Lung Disease: Causes, Diagnosis and Treatment, the authors explore the role of genetics in the pathogenesis of interstitial lung diseases, as well as develop new diagnostic modalities and identify novel therapeutic targets. This compilation goes on to discuss acute infiltrative lung disease, a heterogeneous group of lung disorders characterized by diffuse parenchymal lung involvement. This group of infiltrative lung diseases may result in five histopathological presentations: diffuse alveolar damage, diffuse alveolar hemor...
Pulmonary Hypertension and Interstitial Lung Disease
The first edition of this book, published in 2009, was the only book of its kind dedicated exclusively to the diagnosis and management of pulmonary arterial hypertension (PAH) in patients with interstitial lung disease (ILD). Over the past few years, new diagnostic tests and treatments of pulmonary arterial hypertension have been developed and tested. Diagnostic testing has led to more frequent and specific diagnosis in PAH patients, leading to the more widespread use of effective treatment and improved quality of life and reduction of mortality for PAH patients. Pulmonary Hypertension and Interstitial Lung Disease: A Clinical Guide, Second Edition provides an updated and expanded state-of-t...
Pulmonary Arterial Hypertension and Interstitial Lung Diseases
Interstitial lung disease (ILD) is a broad category of lung diseases that includes more than 150 disorders characterized by scarring or fibrosis of the lungs. In Pulmonary Arterial Hypertension and Interstitial Lung Disease: A Clinical Guide, renowned experts provide a state-of-the-art overview of the problems seen by physicians in the clinical management of ILDs. Divided into two sections, the first part provides and update on general issues and introduces both interstitial lung disease and associated pulmonary hypertension. A detailed analysis of the pathology of the various interstitial lung diseases is also provided. The second part addresses specific categories of disease. Bronchiolitis, hypersensitivity pneumonitis, and other conditions are covered, and the use of inspiratory and expiratory high resolution CT scan is discussed as well. This important new text is an invaluable resource for the practicing physician who must be aware of the broad and troubling manifestations of interstitial lung disease.
Plant Centromere Biology
Plant Centromere Biology is dedicated to plant centromere research. Chapters cover the structure of centromeres from several plant species including Arabidopsis thaliana, rice, maize, wheat and beet, while other sections cover several unique characteristics associated with plant centromeres, including classical and modern neocentromeres, centromere drive and centromere misdivision. Additional chapters are dedicated to epigenetic modification and evolution of plant centromeres, and development and application of plant artificial chromosomes. Written by an international group of experts in the field, Plant Centromere Biology is a valuable handbook for all plant scientists working on plant genome research. Beyond the bench, it can also serve as a helpful reference tool or textbook for upper level college classes on cytogenetics or genome analysis.
Centromere
The centromere is a chromosomal region that enables the accurate segregation of chromosomes during mitosis and meiosis. It holds sister chromatids together, and through its centromere DNA–protein complex known as the kinetochore binds spindle microtubules to bring about accurate chromosome movements. Despite this conserved function, centromeres exhibit dramatic difference in structure, size, and complexity. Extensive studies on centromeric DNA revealed its rapid evolution resulting often in significant difference even among closely related species. Such a plasticity of centromeric DNA could be explained by epigenetic c- trol of centromere function, which does not depend absolutely on prima...
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