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Drug delivery systems represent a vast area of research and development within biomaterials and medicine and the demand for sophisticated drug delivery devices continues to drive novel product development. Advanced drug delivery devices can offer significant advantages over conventional drugs and devices alone, such as increased efficiency, improved performance and convenience. The purpose of this book is to illustrate how effective drug delivery can be achieved by means other than tablets. The book will provide a thorough analysis of the fundamentals, applications and new technologies of drug-device combination products for use throughout the human body.Part one provides readers with an int...
Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis. This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo. - Provides a specific focus on cardiovascular stents - Includes a range of topics covering the fundamentals, surface modification and biofunctionalization - Provides essential knowledge for researchers on advances in the field
ISO 14155:2020 addresses good clinical practice for the design, conduct, recording and reporting of clinical investigations carried out in human subjects to assess the clinical performance or effectiveness and safety of medical devices. For post-market clinical investigations, the principles set forth in this document are intended to be followed as far as relevant, considering the nature of the clinical investigation (see Annex I).
Yeast - Industrial Applications is a book that covers applications and utilities of yeasts in food, chemical, energy, and environmental industries collected in 12 chapters. The use of yeasts in the production of metabolites, enzymatic applications, fermented foods, microorganism controls, bioethanol production, and bioremediation of contaminated environments is covered showing results, methodologies, and processes and describing the specific role of yeasts in them. The traditional yeast Saccharomyces cerevisiae is complemented in many applications with the use of less known non-Saccharomyces yeasts that now are being used extensively in industry. This book compiles the experience and know-how of researchers and professors from international universities and research centers.
To execute and guarantee the right to privacy and data protection within the European Union (EU), the EU found it necessary to establish a stable, consistent framework for personal data protection and to enforce it in a decisive manner. This book, the most comprehensive guide available to the General Data Protection Regulation (GDPR), is the first English edition, updated and expanded, of a bestselling book published in Poland in 2018 by a renowned technology lawyer, expert to the European Commission on cloud computing and to the Article 29 Working Party (now: the European Data Protection Board) on data transfers who in fact contributed ideas to the GDPR. The implications of major innovation...
An essay for the stage from 2004 Nobel Prize in Literature Laureate Elfriede Jelinek focusing on the ills of capitalism.
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Software product lines provide a systematic means of managing variability in a suite of products. They have many benefits but there are three major barriers that can prevent them from reaching their full potential. First, there is the challenge of scale: a large number of variants may exist in a product line context and the number of interrelationships and dependencies can rise exponentially. Second, variations tend to be systemic by nature in that they affect the whole architecture of the software product line. Third, software product lines often serve different business contexts, each with its own intricacies and complexities. The AMPLE (http://www.ample-project.net/) approach tackles these three challenges by combining advances in aspect-oriented software development and model-driven engineering. The full suite of methods and tools that constitute this approach are discussed in detail in this edited volume and illustrated using three real-world industrial case studies.
This classic French opera tells the tale of a humble juggler who seeks to honor the Virgin Mary through his art. Despite his lack of traditional religious training, the juggler's pure heart and earnest desire to do good win the admiration and respect of all those around him. With its beautiful music and timeless message of love and devotion, Le Jongleur de Notre Dame / The Juggler of Notre Dame is a must-see for any fan of opera. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.