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The Skadar/Shkodra Lake Environment
This book reviews the unique ecosystem of the Lake Skadar/Shkodra and its basin, and discusses the latest advances made in this region to face the impact of climate change. Divided into 23 chapters, the book gathers leading expertise from various scientific and engineering communities and provides readers with extensive discussions of core issues, including the water and sediment chemistry of Lake Skadar/Shkodra and the metal pollution that is evident in plants, aquatic invertebrates and fish. Readers will discover how a sustainable science-based management approach can be applied to the Lake Skadar/Shkodra region, and will learn about the environment prospects for the region. This book is intended as an essential tool for all scientists interested in the Lake Skadar/Shkodra environment – in particular those investigating the interactions between land and water, between limnology and biota, and between natural and cultural resources.
The Rivers of Montenegro
This book reviews the current state of knowledge on, recent advances in, and future prospects of Montenegrin river basins in the context of anthropogenic activities. Edited by three respected experts in the field, the book begins with an introduction to the specific hydrogeological conditions in Montenegro and critical reflections on the impact of hydropower projects. It then reviews the vulnerability of river ecosystems, exploring potential genotoxic effects and water quality, and explaining typology and monitoring of these aspects, and particularly highlighting mollusk assemblages and monitoring of intermittent rivers. The closing chapters focus on the impact of river flooding and discuss controversial projects aiming to find an approach mutually acceptable to all stakeholders. Given its scope, the book is an indispensable resource for scientists in academia and the water industry, as well as for decision-makers in the field investigating the interactions between land and water, limnology and biota, and natural and cultural resources.
Natural Product Extraction
Natural products are used by the food, pharmaceutical and cosmetics industries, and extraction technologies and potential applications for plant extracts are of interest to many industrial sectors. Extraction of natural products in an economic and environmentally friendly way is of high importance to all industries involved. The second edition of this book presents an updated, holistic, in-depth view of the more environmentally benign techniques available for the extraction of natural products, along with their newest applications and case studies. Conventional and emerging extraction techniques are discussed in detail. New topics include enzymes, pulsed electric energy, and on-line/in-line analysis. Written for academics and industrialists working in both natural product extraction and green chemistry, this new edition provides a valuable update on current trends in the field.
Supercritical and Other High-pressure Solvent Systems
This book brings together recent advances in supercritical technology and other pressurised-solvent systems.
Genetic Polymorphism and Disease
Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases espe...
Drug Discovery for Schizophrenia
Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, pointing to a general stagnation in the field of pharmacology of schizophrenia. Drug Discovery for Schizophrenia covers new insights in the field of schizophrenia with an aim to advance the understanding of scientists and clinicians in this area and to fuel drug discovery. The book outlines a change in the way schizophrenia is treated by moving away from focusing only on treating symptoms in patients. Innovative drugs emerge from deeper comprehension of the pathological processes that emerge earlier in life, hence, providing strategies for preventative therapy to alter the course of this mental disorder. Amongst other current topics, the book covers new findings in genetics and epigenetics, progress in animal models for schizophrenia and the usage of induced pluripotent stem cells. The combination of these important areas benefit psychiatric neuroscience, filling the gaps in the knowledge of neurobiology of schizophrenia and providing novel perspectives for future drug development.
Central Functions of the Ghrelin Receptor
The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system. In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein...
Nanocarriers in Neurodegenerative Disorders
Due to the lack of secure, efficient, and patient-friendly therapies for neurodegenerative disorders, there is a rising demand for innovative approaches. Despite the limited number of nanocarriers approved for human use, they have demonstrated significant potential in preclinical and, in some instances, clinical trials. In alignment with this objective, the chapters of the book are structured to offer a comprehensive overview of recent advancements in medication and dosage form development, specifically emphasizing the nanoparticulate system for targeting the brain. This book aims to furnish readers with a thorough understanding of the clinical application of nanocarrier systems for treating...
Electron Kinetics and Applications of Glow Discharges
This book resulted from the NATO Advanced Research Workshop on “Electron Kinetics and Applications of Glow Discharges,” held in St. Petersburg, Russia, on May 19-23, 1997. Glow discharges have found widespread applications in many technological processes from the manufacture of semiconductors, to recent developments in na- technology, to the traditional fields of gas lasers, and discharge lamps. Consequently, the interest in the physics of glow discharges has experienced yet another resurgence of interest. While the non-equilibrium character of glow discharges is widely accepted, the opinion still prevails that the main features can be captured by fluid models, and that kinetic treatments are only required for the understanding of subtle details. The erroneousness of this belief is demonstrated by the failure of fluid models to describe many basic features of glow discharges such as, for instance, electrode phenomena, striations, and collisionless heating effects. An adequate description of glow discharges thus has to be of kinetic nature.
