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Drug Discovery and Drug Development
Over the years, India has attained a prominent global position in the manufacture of Generic Drugs. This success can be attributed to its synthetic organic chemistry and chemical engineering strengths, nurtured by the timely policies of the Government of India. However, breakthrough successes in New Drug Discovery have remained elusive, despite the brilliant and sustained efforts of many Indian researchers and Pharma establishments. The Indian National Science Academy thought it appropriate to document India’s New Drug Discovery Research (NDDR) journey to date. Gathering contributions from prominent researchers in the Indian Pharma Industry and Academia, this book highlights their efforts, achievements, and the status quo of Indian NDDR.
Natural Products Targeting Clinically Relevant Enzymes
The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
The Role of Nanoparticles in Plant Nutrition under Soil Pollution
Nanotechnology has shown great potential in all spheres of life. With the increasing pressure to meet the food demands of rapidly increasing population, thus, novel innovation and research are required in agriculture. The principles of nanotechnology can be implemented to meet the challenges faced by agricultural demands. Major challenges include the loss of nutrients in the soil and nutrient-deficient plants, which result in a lower crop yield and quality. Subsequently, consumption of such crops leads to malnourishment in humans, especially in underprivileged and rural populations. One convenient approach to tackle nutrient deficiency in plants is via the use of fertilizers; however, this m...
State-of-the-Art Program on Compound Semiconductors 51 (SOTAPOCS 51) and Wide-Bandgap Semiconductor Materials and Devices 10
The papers included in this issue of ECS Transactions were originally presented in the joint symposium ¿State-of-the-Art Program on Compound Semiconductors 51 (SOTAPOCS 51) and Wide-Bandgap Semiconductor Materials and Devices 10¿, held during the 216th meeting of The Electrochemical Society, in Vienna, Austria from October 4 to 9, 2009.
Molecular Level Atomistic and Structural Insights on Biological Macromolecules, Inhibition, and Dynamics Studies
Everything in a living organism relies on biological macromolecules, which have the role of enzymatic chemical transformations, formation of structures, transportation, catalysis, and regulation of biological processes. They are complex biological structures that require an atomistic understanding. A molecular understanding of biological macromolecules has had a massive impact on the pharmaceutical, biotechnological, and chemical industries. Specifically, new enzymatic structures are being discovered through various experimental and computational methods, by describing an atomistic-level insight into function, mechanism, role in reactions and their inhibition. Those atom-level illustrations are mainly focused through enzyme kinetics, enzyme inhibition, mutational and conformational analysis through quantum mechanical and molecular dynamics methods.
Novel Approach to Sustainable Temperate Horticulture
In the current scenario, marked by a continual improvement in living standards, it becomes imperative to boost the productivity as well as the efficiency of agriculture, especially horticulture, which holds the potential for significant economic prosperity aligning with Sustainable Development Goal number 8, "Decent Work and Economic Growth". Modern technological interventions, such as geospatial technology and geographic information system (GIS) technology, can be harnessed to yield effective results in addressing challenges and providing enhanced decision support, particularly in the planning of horticultural resource management. Cultivation and production of fresh produce face several cha...
Exploring and Optimizing Agricultural Landscapes
The book informs about agricultural landscapes, their features, functions and regulatory mechanisms. It characterizes agricultural production systems, trends of their development, and their impacts on the landscape. Agricultural landscapes are multifunctional systems, coupled with all nexus problems of the 21th century. This has led to serious discrepancies between agriculture and environment, and between urban and rural population. The mission, key topics and methods of research in order to understanding, monitoring and controlling processes in rural landscapes is being explained. Studies of international expert teams, many of them from Russia, demonstrate approaches towards both improving agricultural productivity and sustainability, and enhancing ecosystem services of agricultural landscapes. Scientists of different disciplines, decision makers, farmers and further informed people dealing with the evolvement of thriving rural landscapes are the primary audience of this book.
Maize
Maize is widely cultivated throughout the world due to its high-yield potential. The economic and nutritional value of maize grains is associated with its starch content, protein, fibre, bioactive compounds, and minerals. Maize is used worldwide in the preparation of health-benefiting, antioxidant-rich, fortified products and dietary supplements. Maize: Nutritional Composition, Processing, and Industrial Uses explores the status of maize in terms of its production, nutritional composition, biofortification, processing methods, health benefits, maize-based products and storage. This book also emphasizes the key features of maize grains which make it an ideal crop for industrial use. It covers...
Plant Performance Under Environmental Stress
Global climate change is bound to create a number of abiotic and biotic stresses in the environment, which would affect the overall growth and productivity of plants. Like other living beings, plants have the ability to protect themselves by evolving various mechanisms against stresses, despite being sessile in nature. They manage to withstand extremes of temperature, drought, flooding, salinity, heavy metals, atmospheric pollution, toxic chemicals and a variety of living organisms, especially viruses, bacteria, fungi, nematodes, insects and arachnids and weeds. Incidence of abiotic stresses may alter the plant-pest interactions by enhancing susceptibility of plants to pathogenic organisms. ...
