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During the past ten years, several theories have been proposed on the origin of the diversity of antibodies. George P. Smith presents a critical study of these theories in this detailed treatment of immunological problems from the point of view of molecular genetics. Mr. Smith uses a new and simplifying approach to this long-standing controversy. By a comprehensive computerized analysis of antibody amino acid sequences (particularly the myeloma proteins), the author traces their evolution and matches his results against the expectations of the various theories of diversity. He discusses at length the other types of evidence as well. Mr. Smith also deals with the clonal specialization of cells to produce a single antibody, and the relationship of this specialization to the somatic joining of antibody half-genes, which is one of the immune system's most important peculiarities. Introductory material is provided to make this work understandable to molecular geneticists not versed in immunology and to immunologists not versed in molecular genetics. This is a timely book offering a succinct and coherent summary of the various lines of evidence in a confused and controversial field.
Intended for the undergraduate students of mathematics, this student-friendly text provides a complete coverage of all topics of Linear, Abstract and Boolean Algebra. The text discusses the matrix and determinants, Cramer’s rule, Vandermonde determinants, vector spaces, inner product space, Jacobi’s theorem, linear transformation, eigenvalues and eigenvectors. Besides, set theory, relations and functions, inclusion and exclusion principle, group, subgroup, semigroup, ring, integral domain, field theories, Boolean algebra and its applications have also been covered thoroughly. Each concept is supported by a large number of illustrations and 600 worked-out examples that help students understand the concepts in a clear way. Besides, MCQs and practice exercises are also provided at the end of each chapter with their answers to reinforce the students’ skill.
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Bolshevik Women is a history of the women who joined the Soviet Communist Party before 1921. The book examines the reasons these women became revolutionaries, the work they did in the underground before 1917, their participation in the revolution and civil war, and their service in the building of the USSR. Drawing on a database of more than five hundred individuals as well as on intensive research into the lives of the most prominent female Bolsheviks, the study argues that women were important members of the Communist Party at its lower levels during its formative years. They were lieutenants, printing leaflets, speaking to crowds, and running party operations in the cities. They also created one of the most remarkable efforts to emancipate women from traditional society of the twentieth century. This book traces their fascinating lives from the earliest years of the revolutionary movement through to their old age in the time of Khrushchev and Brezhnev.
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Presents all the 195 Yoga Sutras professed by the legendary Maharishi PATANJALI. He affirmed that Yoga is not only limited to Āsanas, but also aims at outer and inner purification; control and balance of the self; meditation and complete absorption. And finally union with the Self. Contains 4 Chapters: Samadhi; Sadhana; Vibhuti and Kaivalya. Comprises of all the 8 limbs of Ashtanga Yoga: 5 external and 3 internal, Yama; Niyama; Asana; Pranayama; Pratyahara; Dharana; Dhyana; and Samadhi. The book fully utilizes available technology to aid elaboration of the commentary on Yoga Sutras which are admittedly terse. Charts and tables as well as graphs and pictures adore the book practically on every page so that the reader finds it helpful to enhance his understanding. Stories and quotations from the spiritual greats are added to widen comprehension. This then is a book that is truly unique in its presentation that would find ready acceptance by Yoga teachers and students alike all over the world. All those students and teachers of Yogasanas who wish to go beyond Asanas and aim at avoidance of mental modifications and the resultant stressful life would find this book a boon.
A panel of leading experts integrate the latest findings from basic and clinical science to create a comprehensive treatment of the processes by which the brain acts as an endocrine organ, not only to control hormonal functions, but also to maintain homeostasis and regulate behavior. The authors-recognized both as leaders in their fields and as skilled teachers-provide systematic coverage of the analytical, anatomical, functional, clinical, and pathological aspects of neuroendocrinology. Topics range from the interactions between the nervous and endocrine systems to the regulation of reproduction, development, metabolism, fluid balance, and biological rhythms. Neuroendocrinology in Physiology and Medicine offers an unprecedented marriage of clinical and basic knowledge that has been missing from classical neuroscience, endocrinology, and physiology texts. It will teach today's medical students and serve researchers as a valuable reference to this rapidly growing field.
The volume is dedicated to Professor David Elworthy to celebrate his fundamental contribution and exceptional influence on stochastic analysis and related fields. Stochastic analysis has been profoundly developed as a vital fundamental research area in mathematics in recent decades. It has been discovered to have intrinsic connections with many other areas of mathematics such as partial differential equations, functional analysis, topology, differential geometry, dynamical systems, etc. Mathematicians developed many mathematical tools in stochastic analysis to understand and model random phenomena in physics, biology, finance, fluid, environment science, etc. This volume contains 12 comprehe...
The text of this book is derived from courses taught by the author in the Department of Applied Mathematics and Statistics at the State University of New York at Stony Brook. The audience for these courses was composed almost entirely of fourth year undergraduate students majoring in the mathematical sciences. The students had ordinarily completed four semesters of calculus and one of probability. Few had any prior experience with differential equations, stochastic processes, or epidemiology. It also seems prudent to mention that the author's background is in engineering and applied mathematics and not in epidemiology; it is hoped that this is not painfully obvious. The topics covered in thi...