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Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies
This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.
Microbial Inoculants
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Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile
For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer trea...
Drug Stability and Chemical Kinetics
This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics.
Novel Strategies and Approaches in Hypertension Therapy
INTRODUCTION: Hypertension has become a major public health problem in the last few decades. High blood pressure is a serious risk factor for premature cardiovascular disease and end-organ damage including left-ventricular hypertrophy and congestive heart failure, which in turn increases the risk of cardiovascular morbidity and mortality. While studies of hypertension have been performed worldwide in a variety of epidemiological settings such as diabetes, renal function, obesity and thyroid disorders, there is a need to identify appropriate treatment strategies Novel Strategies and Approaches in Hypertension introduces the reader to different aspects of hypertension treatment (environmental ...
Advances in Business Informatics empowered by AI & Intelligent Systems
Information Technology is the most significant development in the recent past, and different subfields and technologies have emerged in recent past such as Artificial Intelligence, Cloud Computing, Big data, Internet of Things, Business Analytics, Information Assurance, and Cyber Security, Robotics for sophisticated Business Informatics practice. Such effective Business Informatics is fruitful in sophisticated information and technological services to industries and organizations. Technology is required in various tangible and intangible product and service based organizations, businesses, and enterprises. In managing organizations role of information and content is just perfect not only for...
Biocontrol of Major Grapevine Diseases
Biocontrol of major grapevine diseases provides a timely research update on the use of biological control agents and plant resistance inducers against phytopathogenic infections of the grapevine by fungi, oomycetes, bacteria and phytoplasma.Taking a holistic approach, this book presents in detail the ecology, mechanisms and the application methods of these agents. Its 19 chapters, authored by international experts, cover diseases such as grey mould, trunk diseases, powdery and downy mildews, as well as phytoplasma diseases, and, by nature, emphasise applications of biocontrol in organic viticulture and as part of integrated pest management systems.
Nanoparticle Toxicity and Compatibility
The book focuses on the interplay between nanoparticles and biological systems. Topics covered include the synthesis, characterization, and application of nanomaterials in tissue engineering; the interaction of nanoparticles with macromolecules; biomedical and food science applications; the cardiovascular toxicity of nanoparticles; colon targeted nano drug delivery systems; the biocompatibility and immunogenicity of nanoparticles; plasmon-enhanced biosensing applications; strategies for enhancing the biocompatibility of nanoparticles; the environmental impact of nanoparticles; as well as the intricate dynamics between nanoparticles and living organisms. Keywords: Tissue Engineering, Cardiovascular Toxicity, Drug Delivery Systems, Plasmon-Enhanced Biosensing, Biocompatibility of Nanoparticles, Ecotoxicology of Nanoparticles, Bioinspired Nanosynthesis, Hepatotoxicity, Nano Drug Delivery, Nanofabrication, Nanorobots, Plasmonics, Probiotics, Protein.
Emerging Solutions in Sustainable Food and Nutrition Security
Given the uncertainties in future food and nutrition security due to climate change compounded with an increasing global population, sustainable development is essential for the survival of much of the world's population. Besides the conceptual evolution of food and nutrition security, exploration of new scientific areas aids in reshaping our knowledge of nutritional requirements, and innovation of novel technologies can be utilized to tackle production and security issues in sustainable ways. Emerging Solutions in Sustainable Food and Nutrition Security provides comprehensive and up-to-date coverage of the current problems and issues, emerging ideas, and pragmatic solutions in sustainable n...
Frontiers in Combating Antibacterial Resistance: Current Perspectives and Future Horizons
The rise of modern antimicrobial drug resistance has evolved into a pressing global health crisis, challenging the very foundation of our ability to combat infectious diseases. The overuse and accessibility of antibiotics, particularly in emerging nations, have given rise to resilient "superbugs," rendering common medications ineffective. This escalating challenge poses a significant threat to public health and leads to heightened healthcare costs, prolonged patient stays, and increased mortality rates. As communities grapple with the urgent need for a coordinated response, a comprehensive understanding of antimicrobial drug resistance and innovative strategies becomes paramount. Frontiers i...
