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Implementation Science Meets Software Development to Create EHealth Components for an Integrated Care Model for Allogeneic Stem Cell Transplantation Facilitated by EHealth: the SMILe Study as an Example
Abstract: Purpose To describe a process of creating eHealth components for an integrated care model using an agile software development approach, user-centered design and, via the Behavior Change Wheel, behavior theory-guided content development. Following the principles of implementation science and using the SMILe project (integrated care model for allogeneic stem cell transplantation facilitated by eHealth) as an example, this study demonstrates how to narrow the research-to-practice gap often encountered in eHealth projects. Methods We followed a four-step process: (a) formation of an interdisciplinary team; (b) a contextual analysis to drive the development process via behavioral theory...
Context-specific Adaptation of an EHealth-facilitated, Integrated Care Model and Tailoring Its Implementation Strategies - a Mixed-methods Study as a Part of the SMILe Implementation Science Project
Abstract: Background: Contextually adapting complex interventions and tailoring their implementation strategies is key to a successful and sustainable implementation. While reporting guidelines for adaptations and tailoring exist, less is known about how to conduct context-specific adaptations of complex health care interventions. Aims: To describe in methodological terms how the merging of contextual analysis results (step 1) with stakeholder involvement, and considering overarching regulations (step 2) informed our adaptation of an Integrated Care Model (ICM) for SteM cell transplantatIon faciLitated by eHealth (SMILe) and the tailoring of its implementation strategies (step 3). Methods: S...
Blood and Marrow Transplantation Long Term Management
Blood and Marrow Transplantation Long Term Management Hematopoietic cell transplantation (HCT) provides curative therapy for a variety of diseases. Over the past several decades, significant advances have been made in the field of HCT, to the point where HCT has become an integral part of treatment modality for a variety of hematologic malignancies and some nonmalignant diseases. HCT remains an important treatment option for a wide variety of hematologic and nonhematologic disorders, despite recent advances in the field of immunologic therapies. Factors driving this growth include expanded disease indications, greater donor options (expanding unrelated donor registries and haploidentical HCT...
Development of an Integrated Model of Care for Allogeneic Stem Cell Transplantation Facilitated by EHealth - the SMILe Study
Abstract: Purpose Allogeneic stem cell transplantation would benefit from re-engineering care towards an integrated eHealth-facilitated care model. With this paper we aim to: (1) describe the development of an integrated care model (ICM) in allogeneic SteM-cell-transplantatIon faciLitated by eHealth (SMILe) by combining implementation, behavioral, and computer science methods (e.g., contextual analysis, Behavior Change Wheel, and user-centered design combined with agile software development); and (2) describe that model's characteristics and its application in clinical practice. Methods The SMILe intervention's development consisted of four steps, with implementation science methods informin...
Trimesityltriangulene: a Persistent Derivative of Clar's Hydrocarbon
Abstract: Triangulene, known as Clar's hydrocarbon, is a prototypical non-Kekulé diradical comprised of six benzenoid rings fused in a triangular shape. We synthesized and characterized its trimesityl derivative, illustrating that three bulky substituents installed in the centers of the zigzag edges suffice to protect all reactive positions. This work brings prospects to use triangulene and its open-shell analogs in spintronic materials via solution-phase synthesis
Allergens and Allergen Immunotherapy
Updated and substantially enlarged from the 1991 Allergen Immunotherapy to incorporate the many new therapies to treat allergic and immunological disease, many developed by applying the methods of molecular biology. Presents the basic principles of immunotherapy with allergens as perhaps the best chance for producing someday a specific cure for allergic illness. Describes in detail the various allergen groups, such as trees, grasses, weeds, molds, Hymenoptera and other insect allergens, mammalian allergens, latex, drugs, and foods. Defines the biochemical and molecular characteristics by which allergens are manufactured and standardized for optimal use in diagnosis and immunotherapy, including many that have now been cloned and expressed as homogeneous recombinant antigens and proteins. Also presents the scientific data on immunotherapeutic procedures to treat various allergic diseases and how such therapy modifies the immunological process responsible for IgE-mediated disease. Annotation copyrighted by Book News, Inc., Portland, OR
Vaccines against Allergies
We are celebrating this year the hundred years ́ anniversary of allergen-specific immunotherapy. In 1911 Leonard Noon published his seminal work “Prophylactic inoculation against hay fever” describing his attempts to achieve active immunity against “grass pollen toxin” by administering increasing doses of grass pollen extract before the grass pollen season to allergic patients. Although it was unknown at that time that allergy represents an immunological hypersensitivity disease, the treatment was effective and many observations made by Noon remained valid until today. Today allergen-specific immunotherapy is well established as the only allergen-specific and disease-modifying treatment for IgE-mediated allergies and has long-lasting effects. In fact, more than 25% of the population suffer from IgE-mediated allergies which therefore represent a major health burden of our society, particularly because untreated allergy often progresses to severe disabling forms of disease, such as asthma and sometimes kills sensitized people through anaphylaxis.
The Astrophysical Journal
"Letters to the Editor" issued as Part 2 and separately paged from v. 148, 1967. Beginning in 2009, the Letters published only online.
