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Structure-based Design of Drugs and Other Bioactive Molecules
Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present "best practice" methods in structurebased drug design with both ...
Ethnicity and Old Age
Winner of the Richard Kalish Innovative Publication Award 2021. Part of the Ageing in a Global Context series, this book proposes a new research agenda for scholarship that focuses on ethnicity, race and old age. It argues that in a time of increased international migration, population ageing and ethno-cultural diversity, scholarly imagination must be expanded as current research frameworks are becoming obsolete. By bringing attention to the way that ethnicity and race have been addressed in research on ageing and old age, with a focus on health inequalities, health and social care, intergenerational relationships and caregiving, the book proposes how research can be developed in an ethnicity astute and diversity informed manner.
Proceedings of the 20th Congress of the International Ergonomics Association (IEA 2018)
This book presents the proceedings of the 20th Congress of the International Ergonomics Association (IEA 2018), held on August 26-30, 2018, in Florence, Italy. By highlighting the latest theories and models, as well as cutting-edge technologies and applications, and by combining findings from a range of disciplines including engineering, design, robotics, healthcare, management, computer science, human biology and behavioral science, it provides researchers and practitioners alike with a comprehensive, timely guide on human factors and ergonomics. It also offers an excellent source of innovative ideas to stimulate future discussions and developments aimed at applying knowledge and techniques...
Current Perspectives on Literary Reading
This collection aims to provide answers regarding what the most recent trends are in research in literary reading. Based on that premise, it contains a rigorously selected and varied roster of investigations that focus on presenting and attempting to interpret and understand the most recent literary trends or tendencies, as well as the reasons for the propensities they create among the masses of young and adult readers. This selection of texts in English, Catalan and Spanish will give the reading specialist an idea of where today’s trends are headed, and how they point towards the formation of a new paradigm in matters of literature.
Structure-Based Drug Design for Diagnosis and Treatment of Neurological Diseases
European Cooperation in Science and Technology (COST) supports the collaboration of nationally-funded science and technology research through the creation of networks. COST is the longest-running European framework enhancing cooperation among researchers, engineers and scholars across Europe. The COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” is a good example of the advances possible through interdisciplinary collaboration on difficult problems. COST Action CM1103 brought together 28 research groups from 18 countries to collaborate for four years o...
Necessary as Blood
Once the haunt of Jack the Ripper, London's East End is a vibrant mix of history and new ideas, but the trendy galleries of Brick Lane disguise a seedy underside where unthinkable crimes bring terror to the innocent. Artist and young mother Sandra Gilles disappears without trace after leaving her three-year-old daughter, Charlotte, with a friend at the Columbia Road Flower Market. Her lawyer husband, Naz Malik, is devastated - but he's also the prime suspect in a murder investigation. When Naz vanishes shortly afterwards, Gemma James and her partner Superintendent Duncan Kincaid agree to work together again to solve the case before the murderer can get his hands on the real prize, Charlotte. But just as the case grows more dangerous, a personal issue threatens to throw Gemma and Duncan off the trail. In the end, it is up to them to stop a vicious killer and protect the child whose fate hangs in the balance.
Medicinal Chemistry Approaches to Malaria and Other Tropical Diseases
Medicinal Chemistry Approaches to Malaria and Other Tropical Disease, Volume 53 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Annual Reports in Medicinal Chemistry series - Includes the latest information on Medicinal Approaches to Malaria and Other Tropical Diseases
In Silico Methods for Drug Design and Discovery
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Lloyd’s Register of Yachts 1923
The Lloyd’s Register of Yachts was first issued in 1878, and was issued annually until 1980, except during the years 1916-18 and 1940-46. Two supplements containing additions and corrections were also issued annually. The Register contains the names, details and characters of Yachts classed by the Society, together with the particulars of other Yachts which are considered to be of interest, illustrates plates of the Flags of Yacht and Sailing Clubs, together with a List of Club Officers, an illustrated List of the Distinguishing Flags of Yachtsmen, a List of the Names and Addresses of Yacht Owners, and much other information. For more information on the Lloyd’s Register of Yachts, please click here: https://hec.lrfoundation.org.uk/archive-library/lloyds-register-of-yachts-online
