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In Vivo Evaluation of Bioprinted Prevascularized Bone Tissue
Abstract: Bioprinting can be considered as a progression of the classical tissue engineering approach, in which cells are randomly seeded into scaffolds. Bioprinting offers the advantage that cells can be placed with high spatial fidelity within three-dimensional tissue constructs. A decisive factor to be addressed for bioprinting approaches of artificial tissues is that almost all tissues of the human body depend on a functioning vascular system for the supply of oxygen and nutrients. In this study, we have generated cuboid prevascularized bone tissue constructs by bioprinting human adipose-derived mesenchymal stem cells (ASCs) and human umbilical vein endothelial cells (HUVECs) by extrusio...
It's Up to You... What Do You Do?
This work is intended for ages 4-8. If a friend had wronged you, how would you react? What if someone could give you all the answers to a big test in school? Is there an "easy way out" of hard work? Is being "popular" important? From about age six through elementary school and junior high, young people are exposed almost daily to questions of personal values just like these and their responses help to develop those unique virtues that govern their actions for years to come. The twenty-five contemporary anecdotes in this book offer challenging situations involving school-age children who must make their own choices in life. Whether reading alone or sharing these stories with an adult, young readers are asked to think about what they would do. Sandra McLeod Humphrey defines the principles that support strong character: personal integrity, compassion, loyalty, perseverance, self-discipline, personal accountability, and many others. Far more important than reaching a "correct" answer is the process of arriving at a well-reasoned conclusion.
Metabolism of Drugs and Other Xenobiotics
A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Sandra Bullock
One of the most acclaimed actresses of the last two decades, Sandra Bullock has managed to skillfully shift between action roles? ?and more serious dramatic? ?parts throughout her long career.? She has? ?also taken an active role in humanitarian issues, donating? ?one million? ?dollars to relief efforts in Haiti after the 2010 earthquake, among other causes. This compelling volume provides an incisive biography of Sandra Bullock. Chapters include her childhood, her breakthrough into Hollywood with the movie Speed, making movies as a producer, and a year of personal triumphs and challenges.
Aquarius Now
What Thomas Paine did for the American Revolution with the publication of Common Sense, Marilyn Ferguson does for the transpersonal revolution with the publication of this astonishing call to internal arms. Marilyn Ferguson is one of the preeminent thinkers, gatherers, synthesizers, and interpreters of research on all the cutting-edge fields of human consciousness. The Aquarian Conspiracy, published in 1980, has sold 2.5 million copies and has been continuously in print. The book was hailed as the "handbook of the New Age," by USA Today and is widely regarded as one of the most important books of the twentieth century as the harbinger of a new segment of society stemming from the "vastly enl...
Kids Can't Wait
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Sandra Russell Clark
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