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The Anatomical and Phylogenetic Nature of the First Mitochondrial Ancestor
Mitochondria are cell organelles that evolved by endosymbiosis. Even though the nature of the last mitochondrial common ancestor is well constrained, little is known about the nature of the first mitochondrial common ancestor. The goal of this thesis was to shed light on the anatomy and genealogy of the first mitochondrial ancestor. Mitochondria compartmentalizes aerobic respiration inside membrane invaginations called cristae. The development of mitochondrial cristae involves the MICOS (Mitochondrial Contact Site and Cristae Organizing System) complex. I show that the core of MICOS, Mic60, is conserved across eukaryotes and was inherited from the alphaproteobacterial ancestor of mitochondri...
Structure and Function
The history of biology is mottled with disputes between two distinct approaches to the organic world: structuralism and functionalism. Their persistence across radical theory change makes them difficult to characterize: the characterization must be abstract enough to capture biologists with diverse theoretical commitments, yet not so abstract as to be vacuous. This Element develops a novel account of structuralism and functionalism in terms of explanatory strategies (Section 2). This reveals the possibility of integrating the two strategies; the explanatory successes of evolutionary-developmental biology essentially depend on such integration (Section 3). Neither explanatory strategy is universally subordinate to the other, though subordination with respect to particular explanatory tasks is possible (Section 4). Beyond structuralism and functionalism, philosophical analysis that centers explanatory strategies can illuminate conflicts within evolutionary theory more generally (Section 5).
Homologue Replacement in the Import Motor of the Mitochondrial Inner Membrane of Trypanosomes
Abstract: Many mitochondrial proteins contain N-terminal presequences that direct them to the organelle. The main driving force for their translocation across the inner membrane is provided by the presequence translocase-associated motor (PAM) which contains the J-protein Pam18. Here, we show that in the PAM of Trypanosoma brucei the function of Pam18 has been replaced by the non-orthologous euglenozoan-specific J-protein TbPam27. TbPam27 is specifically required for the import of mitochondrial presequence-containing but not for carrier proteins. Similar to yeast Pam18, TbPam27 requires an intact J-domain to function. Surprisingly, T. brucei still contains a bona fide Pam18 orthologue that, while essential for normal growth, is not involved in protein import. Thus, during evolution of kinetoplastids, Pam18 has been replaced by TbPam27. We propose that this replacement is linked to the transition from two ancestral and functionally distinct TIM complexes, found in most eukaryotes, to the single bifunctional TIM complex present in trypanosomes
Project Management and Engineering Research
This book gathers the best papers presented at the 19th International Congress on Project Management and Engineering, which was held in Granada, Spain in July 2015. It covers a range of project management and engineering contexts, including: civil engineering and urban planning, product and process engineering, environmental engineering, energy efficiency and renewable energies, rural development, information and communication technologies, safety, labour risks and ergonomics, and training in project engineering. Project management and engineering is taking on increasing importance as projects continue to grow in size, more stakeholders become involved, and environmental, organisational and technological issues become more complex. As such, this book offers a valuable resource for all professionals seeking the latest material on the changing face of project management.
19th International Congress on Project Management and Engineering
Libro de resúmenes del XIX Congreso Internacional de Dirección e Ingeniería de Proyectos (CIDIP 2015) celebrado en Granada
The Gene's-Eye View of Evolution
"To many evolutionary biologists, the central challenge of their discipline is to explain adaptation, the appearance of design in the living world. With the theory of evolution by natural selection, Charles Darwin elegantly showed how a purely mechanistic process can achieve this striking feature of nature. Since then, the way many biologists have thought about evolution and natural selection is as a theory about individual organisms. Over a century later, a subtle but radical shift in perspective emerged with the gene's-eye view of evolution in which natural selection was conceptualized as a struggle between genes for replication and transmission to the next generation. This viewpoint culmi...
She Has Her Mother's Laugh
SHORTLISTED FOR THE 2018 BAILLIE GIFFORD PRIZE FOR NON-FICTION She Has Her Mother’s Laugh presents a profoundly original perspective on what we pass along from generation to generation. Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities . . . But, award-winning science writer Carl Zi...
Decolonizing Latinx Masculinities
Latinx hypersexualized lovers or kingpin predators pulsate from our TVs, smartphones, and Hollywood movie screens. Tweets from the executive office brand Latinxs as bad-hombre hordes and marauding rapists and traffickers. A-list Anglo historical figures like Billy the Kid haunt us with their toxic masculinities. These are the themes creatively explored by the eighteen contributors in Decolonizing Latinx Masculinities. Together they explore how legacies of colonization and capitalist exploitation and oppression have created toxic forms of masculinity that continue to suffocate our existence as Latinxs. And while the authors seek to identify all cultural phenomena that collectively create redu...
Plastid Genome Evolution
Plastid Genome Evolution, Volume 85 provides a summary of recent research on plastid genome variation and evolution across photosynthetic organisms. It covers topics ranging from the causes and consequences of genomic changes, to the phylogenetic utility of plastomes for resolving relationships across the photosynthetic tree of life. This newly released volume presents thorough, up-to-date information on coevolution between the plastid and nuclear genomes, with chapters on plastid autonomy vs. nuclear control over plastid function, establishment and genetic integration of plastids, plastid genomes in alveolate protists, plastid genomes of glaucophytes, the evolution of the plastid genome in chlorophyte and streptophyte green algae, and more. Provides comprehensive coverage of plastid genome variation by leading researchers in the field Presents a broad range of taxonomic groups, ranging from single and multicellular algae, to the major clades of land plants Includes thorough, up-to-date information on coevolution between the plastid and nuclear genomes
