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Archaeology and History of Toraijin
In light of the recently uncovered archaeological data and ancient historical records, this book offers an overview of the 14 centuries-long Toraijin story, from c. 800~600 BC to AD 600, exploring the fundamental role these immigrants, mainly from the Korean Peninsula, played in the history of the Japanese archipelago during this formative period.
S-adenosylmethionine-dependent Methyltransferases
This invaluable volume, written by an international group of scientists, presents an overview of the AdoMet-dependent methyltransferases, with special emphasis on structure-function relationships. S-adenosyl-L-methionine (AdoMet) is the second most commonly used enzyme cofactor after ATP. The AdoMet-dependent methyltransferases act on a wide variety of target molecules, including DNA, RNA, protein, polysaccharides, lipids and a range of small molecules. The well-conserved architecture of these enzymes, and the implications of this conservation for their evolutionary history, are major themes of this book. The thirteen chapters describe in detail the structures, enzyme kinetics and biological roles of the AdoMet-dependent methyltransferases from a wide range of cell types: plant, animal, bacterial and archaeal.
A Bowl for a Coin
A Bowl for a Coin is the first book in any language to describe and analyze the history of all Japanese teas from the plant’s introduction to the archipelago around 750 to the present day. To understand the triumph of the tea plant in Japan, William Wayne Farris begins with its cultivation and goes on to describe the myriad ways in which the herb was processed into a palatable beverage, ultimately resulting in the wide variety of teas we enjoy today. Along the way, he traces in fascinating detail the shift in tea’s status from exotic gift item from China, tied to Heian (794–1185) court ritual and medicinal uses, to tax and commodity for exchange in the 1350s, to its complete nativizati...
Suffering-Focused Ethics
The reduction of suffering deserves special priority. Many ethical views support this claim, yet so far these have not been presented in a single place. Suffering-Focused Ethics provides the most comprehensive presentation of suffering-focused arguments and views to date, including a moral realist case for minimizing extreme suffering. The book then explores the all-important issue of how we can best reduce suffering in practice, and outlines a coherent and pragmatic path forward. "An inspiring book on the world's most important issue. Magnus Vinding makes a compelling case for suffering-focused ethics. Highly recommended." - David Pearce, author of The Hedonistic Imperative and Can Biotechn...
International Bibliography of Historical Sciences
Verzeichnis der exzerpierton zeitschriften: 1926, p. [XXXI]-LXVII.
Eihei Dogen: Mystical Realist
Eihei Dogen, the founder of the Japanese branch of the Soto Zen Buddhist school, is considered one of the world's most remarkable religious philosophers. Eihei Dogen: Mystical Realist is a comprehensive introduction to the genius of this brilliant thinker. This thirteenth-century figure has much to teach us all and the questions that drove him have always been at the heart of Buddhist practice. At the age of seven, in 1207, Dogen lost his mother, who at her death earnestly asked him to become a monastic to seek the truth of Buddhism. We are told that in the midst of profound grief, Dogen experienced the impermanence of all things as he watched the incense smoke ascending at his mother's fune...
Precision medicine approaches for heterogeneous conditions such as autism spectrum disorders (The need for a biomarker exploration phase in clinical trials - Phase 2m)
Many therapeutic interventions for autism spectrum disorder fail when they are examined in a clinical trial. Frequently, there is a subset of patients that responds very well to the intervention, while others do not, and the overall result does not yield a positive result. As autism spectrum disorder is highly heterogeneous in its underlying genetics and other etiological risk factors, as well as its heterogeneous phenotypic manifestation, this variability in response to any specific treatment is not entirely surprising. However, it remains a challenge to meaningfully subtype this heterogeneity for targeted treatment. The purpose of this research topic is to solicit articles that address the...
Eosinophilic Esophagitis
This volume provides a history of Eosinophilic Esophagitis (EoE), a basic understanding of the physiology of the eosinophil, and a current understanding of the pathophysiology and genetics of EoE. The emphasis is on clinical applications including presenting symptoms, diagnosis and treatment options for patients with EoE. Written by both pediatric and adult experts in the fields of gastroenterology, allergy and pathology, this volume includes the most up to date information. Providing practical information useful in the treatment of patients, this book will be of great value to gastroenterologists, allergists, pathologists, medical residents, fellows, internists, and general practitioners who treat patients with eosinophilic esophagitis.
Handbook of Chiral Chemicals
As pharmaceutical companies look to develop single enantiomers as drug candidates, chemists are increasingly faced with the problems associated with this subclass of organic synthesis. "The Handbook of Chiral Chemicals, Second Edition" highlights the problems associated with the production of chiral compounds on a commercial scale. The handbook fir
Discourse, Tools and Reasoning
To reason is to talk. To think is to use tools. To learn is to join a community of practice. This book explores thought and reasoning as inherently social practices, as actions situated in specific environments of demand, opportunity, and accountability. Authors from diverse disciplines - psychology, sociology, artificial intelligence, linguistics, anthropology - examine how people think and learn in settings as diverse as a factory, a classroom or an airplane cockpit. The tools that people use in these varied settings are both physical technologies and cultural constructions: concepts, structures of reasoning, and forms of discourse. This volume in the NATO Special Programme on Advanced Educational Technology is based on an international conference on situated cognition and learning technologies.
