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Governing after War examines how civilians' and rebels' wartime relations affect post-war state-building, development, and violence. When rebels win the war, how do they govern afterwards? Drawing from multiple cases in Africa, Shelley Liu argues that wartime rebel-civilian ties are important to answer this question. Her findings offer implications for recent rebel victories and, more broadly, for understanding the termination, trajectories, and political legacies of such conflicts around the world.
Multiscale Simulations and Mechanics of Biological Materials A compilation of recent developments in multiscale simulation and computational biomaterials written by leading specialists in the field Presenting the latest developments in multiscale mechanics and multiscale simulations, and offering a unique viewpoint on multiscale modelling of biological materials, this book outlines the latest developments in computational biological materials from atomistic and molecular scale simulation on DNA, proteins, and nano-particles, to meoscale soft matter modelling of cells, and to macroscale soft tissue and blood vessel, and bone simulations. Traditionally, computational biomaterials researchers c...
With life expectancy on the rise, the proportion of people aged 60 or older is projected to account for more than one-fifth of the global population by 2050. Sleep quality is one of the most common health concerns that increases with age. Changes in sleep patterns associated with old age include disturbed sleep onset, an increase in sleep fragmentation, more frequent daytime dysfunction, and less slow-wave sleep than younger adults. Sleep is a complex physiological process critical to our health and survival; the many functions of sleep range from cerebral metabolic waste clearance and energy conservation to supporting cognitive performance and psychological well-being. Insufficient sleep ha...
Chemoinformatics is paramount to current drug discovery. Structure- and ligand-based drug design strategies have been used to uncover hidden patterns in large amounts of data, and to disclose the molecular aspects underlying ligand-receptor interactions. This Research Topic aims to share with a broad audience the most recent trends in the use of chemoinformatics in drug design. To that end, experts in all areas of drug discovery have made their knowledge available through a series of articles that report state-of-the-art approaches. Readers are provided with outstanding contributions focusing on a wide variety of topics which will be of great value to those interested in the many different and exciting facets of drug design.
Active colloids are self-propelled particles, powered by energy harvested from the environment. This field of research has been growing over the past 20 years, attracting researchers from multiple disciplines. Biomedical engineers seek to harness the abilities of motile bacteria, materials chemists are fascinated by the concept of synthetic particles becoming autonomous and the new opportunities this presents, and soft matter physicists see active colloids as a model system for active matter, unravelling the principles of nonequilibrium systems. Beginning with the fundamentals, this book discusses the various types of active colloids, classified by energy source, as well as microbial active colloids. Several chapters are dedicated to theory and modelling, followed by an exploration of major developments and research frontiers. With expert contributions from around the world, this book is a useful reference and a source of inspiration for new and experienced researchers.
Chemical Theory and Multiscale Simulation in Biomolecules: From Principles to Case Studies helps readers understand what simulation is, what information modeling of biomolecules can provide, and how to compare this information with experiments. Beginning with an introduction to computational theory for modeling, the book goes on to describe how to control the conditions of modeling systems and possible strategies for time-cost savings in computation. Part Two further outlines key methods, with step-by-step guidance supporting readers in studying and practicing simulation processes. Part Three then shows how these theories are controlled and applied in practice, through examples and case stud...
"Integrative Approaches to the Molecular Physiology of Inflammation" presents contributions from the many different fields and approaches to the physiology and the molecular origins of inflammation; particularly those that may be involved in the development and evolution of diseased phenotypes. We selected among the wide scope and multiple views used to probe into the molecular origins of complex inflammatory phenotypes. This book consists of an Introductory Editorial and 6 thematic chapters encompassing 24 articles: 17 original research contributions and 7 review articles (5 reviews, 1 systematic review, and 1 minireview). Both, the research papers and the reviews provide varied and insightful approaches to different facets of inflammation with approaches ranging from general inflammation and signaling depictions deeply rooted on functional biology and physiology, to computational systems biology analyses, translational medicine, and pharmacological explorations. Model systems are also quite diverse: human subjects, mice and other mammal models, cell cultures and in silico, complex networks and database studies.
People want to live a healthy and happy later life. A large body of literature shows the close association between health status and happiness and between health and active engagement (in work, exercise, and social and religious activities). However, the causation between the two can run both ways, and it is difficult to determine the causal effect with cross-sectional data. Various authors have shown the significant influence of socioeconomic factors and human needs on older people’s health status and happiness. A better understanding of the factors affecting healthy and happy aging is essential for policymaking to improve the well-being of older people. The availability of data from HRS-...
Over a half century of exploration of the Earth’s space environment, it has become evident that the interaction between the ionosphere and the magnetosphere plays a dominant role in the evolution and dynamics of magnetospheric plasmas and fields. Interestingly, it was recently discovered that this same interaction is of fundamental importance at other planets and moons throughout the solar system. Based on papers presented at an interdisciplinary AGU Chapman Conference at Yosemite National Park in February 2014, this volume provides an intellectual and visual journey through our exploration and discovery of the paradigm-changing role that the ionosphere plays in determining the filling and...