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Parasite, Compartments, and Molecules
Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic to Latin America, standing out as a socio-economic problem for low-income tropical populations. Such disease affects millions of people worldwide and emerges in nonendemic areas due to migration and climate changes. The current chemotherapy is restricted to two nitroderivatives (benznidazole and nifurtimox), which is unsatisfactory due to limited efficacy (particularly in chronic phase) and adverse side effects. T. cruzi life cycle is complex, including invertebrate and vertebrate hosts and three developmental forms (epimastigotes, trypomastigotes, and amastigotes). In this chapter, we will discuss promising cellular and m...
Biology of Trypanosoma cruzi
Trypanosoma cruzi, an important zoonotic protozoan that causes Chagas disease, affects at least 8 million people in Latin America. Chagas disease is an important life-long infection in humans that can be divided into distinct clinical stages: the acute phase, where patient symptoms can vary from asymptomatic to severe; the indeterminate form, which is usually asymptomatic; and the chronic phase, where cardiomyopathy and/or digestive megasyndromes appear. In addition to its medical importance, T. cruzi is an interesting biological model for studying processes such as: (1) cell differentiation, where a non-infective stage transforms into an infective one; (2) cell invasion, where the infective...
Transdisciplinarity and Translationality in High Dilution Research
While evidence for the biological effects of high dilutions (above Avogadro’s number) has been extensively documented since the 1980s, it seems to remain invisible to part of the global scientific community. This book provides investigators and other interested readers with direct access to the latest research, conducted between 2009 and 2019, by members of the Groupe International de Recherche sur l’Infinitésimal, the first international scientific society devoted to scientific studies of high dilutions. As shown here, the state of the art in high dilution research allows answering with a sound, evidence-based “no” to the question “Is homeopathy really that implausible?” Therefore this book is an essential contribution to the ongoing debate on complementary and alternative medicine, much-needed by practitioners, patients, and governments in the formulation of healthcare policies.
Biological Research
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MIOC
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Directory of Graduate Research
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Doença de chagas
Edição comemorativa aos noventa anos da descoberta da doença de Chagas, esta obra propicia a estudantes e pesquisadores brasileiros e latino-americanos uma visão global de questões obscuras da relação Trypanosoma cruzi-hospedeiro - para as quais cientistas de todo o mundo ainda buscam respostas, junto com as ferramentas para a investigação da moléstia - em forma de manual para experimentação animal. O objetivo é municiar a nova geração de cientistas com que o Brasil contará neste início de século e milênio. Eles ainda encontrarão cinco milhões de indíviduos chagásicos, sob o risco de morte por cardiopatia, a desafiar sua capacidade de explicar por que alguns desenvolvem a doença enquanto outros equilibram muito bem o convívio na relação parasita-hospedeiro.
