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Statistical Methods in Epilepsy
Epilepsy research promises new treatments and insights into brain function, but statistics and machine learning are paramount for extracting meaning from data and enabling discovery. Statistical Methods in Epilepsy provides a comprehensive introduction to statistical methods used in epilepsy research. Written in a clear, accessible style by leading authorities, this textbook demystifies introductory and advanced statistical methods, providing a practical roadmap that will be invaluable for learners and experts alike. Topics include a primer on version control and coding, pre-processing of imaging and electrophysiological data, hypothesis testing, generalized linear models, survival analysis,...
Towards an Understanding of Tinnitus Heterogeneity
Tinnitus is the perception of a sound when no external sound is present. The severity of tinnitus varies but it can be debilitating for many patients. With more than 100 million people with chronic tinnitus worldwide, tinnitus is a disorder of high prevalence. The increased knowledge in the neuroscience of tinnitus has led to the emergence of promising treatment approaches, but no uniformly effective treatment for tinnitus has been identified. The large patient heterogeneity is considered to be the major obstacle for the development of effective treatment strategies against tinnitus. This eBook provides an inter- and multi-disciplinary collection of tinnitus research with the aim to better understand tinnitus heterogeneity and improve therapeutic outcomes.
The Safety and Efficacy of Noninvasive Brain Stimulation in Development and Neurodevelopmental Disorders
Noninvasive brain stimulation (including Transcranial Magnetic Stimulation (TMS) and Transcranial Current Brain Stimulation (TCS)) can be used both experimentally and therapeutically. In the experimental domain TMS can be applied in single pulses to depolarize a small population of neurons in a targeted brain region. This protocol can be used, for example, to map cortical motor outputs, study central motor conduction time, or evaluate the cortical silent period (a measure of intracortical inhibition) all of which are relevant to neurodevelopment. TMS can also be applied in pairs of pulses (paired pulse stimulation, ppTMS) where two pulses are presented in rapid succession to study intracorti...
The Reasoning Brain: The Interplay between Cognitive Neuroscience and Theories of Reasoning
Despite the centrality of rationality to our identity as a species (let alone the scientific endeavour), and the fact that it has been studied for several millennia, the present state of our knowledge of the mechanisms underlying logical reasoning remains highly fragmented. For example, a recent review concluded that none of the extant (12!) theories provide an adequate account (Khemlani & Johnson- Laird, 2011), while other authors argue that we are on the brink of a paradigm change, where the old binary logic framework will be washed away and replaced by more modern (and correct) probabilistic and Bayesian approaches (see for example Elqayam & Over, 2012; Oaksford & Chater, 2009; Over, 2009...
The Contribution of Postural Adjustments to Body Balance and Motor Performance
The control of balance by the central nervous system is crucial to maintain our posture and perform efficiently our daily motor tasks. This control requires the development of dynamical phenomena sub-served by highly-coordinated patterns of muscle activation/deactivation disseminated throughout the whole-body and called “postural adjustments”. Establishing the interaction between balance control, locomotion and cognition has important clinical implication, especially in term of falls prevention, and will improve our knowledge on the underlying neural correlates. This Research Topic provides an up-to-date picture of the relationship between postural adjustments, body balance and motor per...
Mapping Psychopathology with fMRI and Effective Connectivity Analysis
There is a growing appreciation that many psychiatric (and neurological) conditions can be understood as functional disconnection syndromes – as reflected in aberrant functional integration and synaptic connectivity. This Research Topic considers recent advances in understanding psychopathology in terms of aberrant effective connectivity – as measured noninvasively using functional magnetic resonance imaging (fMRI). Recently, there has been increasing interest in inferring directed connectivity (effective connectivity) from fMRI data. Effective connectivity refers to the influence that one neural system exerts over another and quantifies the directed coupling among brain regions – and ...
Language beyond Words: The Neuroscience of Accent
Language learning also implies the acquisition of a set of phonetic rules and prosodic contours which define the accent in that language. While often considered as merely accessory, accent is an essential component of psychological identity as it embodies information on origin, culture, and social class. Speaking with a non-standard (foreign) accent is not inconsequential because it may negatively impact communication and social adjustment. Nevertheless, the lack of a formal definition of accent may explain that, as compared with other aspects of language, it has received relatively little attention until recently. During the past decade there has been increasing interest in the analysis of ...
Magnetoencephalography
Magnetoencephalography (MEG) is an invaluable functional brain imaging technique that provides direct, real-time monitoring of neuronal activity necessary for gaining insight into dynamic cortical networks. Our intentions with this book are to cover the richness and transdisciplinary nature of the MEG field, make it more accessible to newcomers and experienced researchers and to stimulate growth in the MEG area. The book presents a comprehensive overview of MEG basics and the latest developments in methodological, empirical and clinical research, directed toward master and doctoral students, as well as researchers. There are three levels of contributions: 1) tutorials on instrumentation, mea...
See through
The problem of visualising multivariate data and tensor fields inherits its complexity from the data it targets. By definition, complex data is "hard to separate, analyse, or solve"1. This becomes evident through the fact that methods for "simple" data such as scalars and vectors do not trivially extend to multivariate data and tensors. In the light of increasing number of output variables from simulation models and measurements, this lack of methods leads to a limited choice in the analysis and to a lower fidelity of the analysis. In addition, split application of established methods to a subset of the data, for example the separate rendering of isosurfaces for the different scalar fields c...
Annual Progress in Child Psychiatry and Child Development 1997
This volume traces the modern critical and performance history of this play, one of Shakespeare's most-loved and most-performed comedies. The essay focus on such modern concerns as feminism, deconstruction, textual theory, and queer theory.
