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Extracellular and Intracellular Signaling
Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
A History of Computing Technology
This revised edition of the popular reference and textbook outlines the historical developments in computing technology. It explains and describes historical aspects of calculation with an emphasis on the physical devices used in different times to aid people in their attempts at automating the process of arithmetic.
The Selma of the North
Between 1958 and 1970, a distinctive movement for racial justice emerged from unique circumstances in Milwaukee. A series of local leaders inspired growing numbers of people to participate in campaigns against employment and housing discrimination, segregated public schools, the membership of public officials in discriminatory organizations, welfare cuts, and police brutality. The Milwaukee movement culminated in the dramaticÑand sometimes violentÑ1967 open housing campaign. A white Catholic priest, James Groppi, led the NAACP Youth Council and Commandos in a militant struggle that lasted for 200 consecutive nights and provoked the ire of thousands of white residents. After working-class m...
Reverse Shoulder Arthroplasty
This masterful book from top experts provides clinical insights on reverse shoulder arthroplasty gleaned from hands-on refinement of shoulder replacement techniques. Years of significant biomechanical and clinical research yielded invaluable knowledge that led to important improvements in functional outcome and implant durability. Among these refinements were stronger polyethylene derivatives, better ingrowth technology, and improved connection devices. As the durability and longevity of implant technology increased, younger active patients became suitable candidates for this procedure. In fact, RSA has played a pivotal role in making shoulder arthroplasty the fastest growing implant technol...
Orthopaedic Basic Science: Foundations of Clinical Practice
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Build your Foundation of Basic Science – from Research to Clinical Application A great tool for MOC preparation! A 'must have' for residency! This fourth edition, developed in a partnership between the American Academy of Orthopaedic Surgeons (AAOS) and the Orthopaedic Research Society (ORS), is your concise and clinically relevant resource for the diagnosis and treatment of musculoskeletal diseases and conditions.
Cardiac Resynchronization Therapy
Cardiac resynchronization therapy (CRT) is one of the most exciting new advances in the treatment of chronic severe (NYHA symptom class) heart failure associated with dyssynchronous ventricular contraction that is refractory to medical treatment. In all randomized trials CR has resulted in improved NYHA symptom class, exercise capacity and quality
Of the Rise and Progress of the Arts and Sciences
Of the Rise and Progress of the Arts and Sciences David Hume Of the Rise and Progress of the Arts and Sciences David Hume "Nothing requires greater nicety, in our inquiries concerning human affairs, than to distinguish exactly what is owing to chance, and what proceeds from causes; nor is there any subject, in which an author is more liable to deceive himself by false subtleties and refinements. To say, that any event is derived from chance, cuts short all farther inquiry concerning it, and leaves the writer in the same state of ignorance with the rest of mankind. But when the event is supposed to proceed from certain and stable causes, he may then display his ingenuity, in assigning these c...
Left Atrial Appendage Closure
Percutaneous left atrial appendage (LAA) closure is an emerging technology for thromboembolic prevention in patients with atrial fibrillation (AF). The first human implantation of an LAA device occurred in 2001, and since then four devices have received CE mark approval. These devices are being widely used in Europe for LAA closure in patients who are poor candidates for long-term oral anticoagulation. In the US, the WATCHMAN device (Boston Scientific) is anticipated to receive FDA approval imminently for AF patients who are warfarin-eligible. This approval is projected to significantly expand the indications for LAA closures worldwide. Thus, the volume of procedures is anticipated to escala...
