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Fish, Fur & Feathers
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Butterflies
In Butterflies: Ecology and Evolution Taking Flight, the world's leading experts synthesize current knowledge of butterflies to show how the study of these fascinating creatures as model systems can lead to deeper understanding of ecological and evolutionary patterns and processes in general. The twenty-six chapters are organized into broad functional areas, covering the uses of butterflies in the study of behavior, ecology, genetics and evolution, systematics, and conservation biology. Especially in the context of the current biodiversity crisis, this book shows how results found with butterflies can help us understand large, rapid changes in the world we share with them—for example, geog...
Drosophila Models for Human Diseases
Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
Eukaryotic DNA Replication
Eukaryotic DNA Replication: A Practical Approach is a comprehensive practical manual, with each of its eleven chapters describing an aspect of the methods currently used to investigate DNA replication in eukaryotes. The sequence of the chapters corresponds roughly to the order of events during DNA replication. The first chapters are concerned with initiation, looking at methods to characterize origins of replication and the proteins that interact with them. There then follow chapters describing protocols for the study of the elongation phase and the synthesis of the telomeres. The final chapters provide a more general overview of the study of DNA replication - including its investigation in model systems such as yeast, xenopus and viruses, and looks into methods used to study DNA:protein interactions that could be applied to the study of replication proteins. This exciting new volume provides over 120 tried and tested protocols for the analysis of eukaryotic DNA replication and will be of major interest to a wide variety of molecular and cell biologists, biochemists and medical researchers.
Molecular Biology of Assemblies and Machines
Molecular Biology of Assemblies and Machines provides a comprehensive narrative of the ways in which macromolecular structures assemble and how they interact with other complexes and organelles in the cell. Richly illustrated in full color, the text is written for advanced undergraduates, graduate students, and researchers in biochemistry, molecular biology, biophysics, cell biology, chemistry, structural biology, immunology, microbiology, and medicine.
Sources, Sinks and Sustainability
Source-sink theories provide a simple yet powerful framework for understanding how the patterns, processes and dynamics of ecological systems vary and interact over space and time. Integrating multiple research fields, including population biology and landscape ecology, this book presents the latest advances in source-sink theories, methods and applications in the conservation and management of natural resources and biodiversity. The interdisciplinary team of authors uses detailed case studies, innovative field experiments and modeling, and comprehensive syntheses to incorporate source-sink ideas into research and management, and explores how sustainability can be achieved in today's increasingly fragile human-dominated ecosystems. Providing a comprehensive picture of source-sink research as well as tangible applications to real world conservation issues, this book is ideal for graduate students, researchers, natural-resource managers and policy makers.
Nucleic Acid Polymerases: The Two-Metal-Ion Mechanism and Beyond
olymerases are the nucleotidyl transferases that are responsible for synthesizing DNA and RNA. They are crucial for essential cellular processes including cellular and viral genome replication, DNA repair and damage tolerance, and transcription. Consistent with their vital roles, polymerases are found in all domains of life. The overall chemistry employed by these enzymes is conserved but there are variations among the different groups of polymerases that confer different substrate specificities and nucleotide incorporation fidelities that allow them to be involved in a wide array of cellular activities. Since polymerases were first isolated more than six decades ago, we have made great progress in understanding how different polymerases have adapted to their specific roles. In this Research Topic we will focus on the enzymatic mechanisms of these enzymes and the relationships between polymerase structure and mechanism, to highlight common themes and unique adaptations.
