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Gene therapy
Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Nanotechnology-based non-viral vectors have been proposed as potential candidates. Various polymeric nanoparticles have been shown to be suitable, with high cellular uptake efficiencies and reduced cytotoxicity. These delivery vectors form condensed complexes with DNA which result in shielding against enzymatic degradation and enhanced cellular targeting. Advantages incl...
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from gen...
Cancer Therapy
While there have been a large number of ongoing research projects and publications on the treatment of cancer, there is a limited number of books related to nanotechnology with emphasis on polymeric nanoparticles in cancer therapy. The book, covering all of the recent research work done on this basis, enlightens researchers and students with the benefits of polymeric nanomaterials in cancer. This book provides exhaustive knowledge on polymeric nanoparticles and cancer. Provides a complete overview of the application of different polymeric nanoparticles in cancer therapeutics: from characterization of nanoparticles to in vitro and in vivo studies. Contains a detailed description of the delivery of therapeutic molecules with different polymers realized with nanomedicine in cancer therapeutics. Discusses newly developed promising polymers in cancer. Describes polymeric nanoparticle and their role in theranostics pertaining to cancer. Reviews clinical relevance of different polymeric formulations in the field of cancer
Theory, Techniques and Applications of Nanotechnology in Gene Silencing
This book focuses on various aspects of nanotechnology based gene silencing. The initial chapters detail the techniques available for in vitro and in vivo characterization of nanoparticles. In the later chapters, exhaustive details about various polymeric systems employed for gene silencing has been accounted.
Nanomaterials: Evolution and Advancement Towards Therapeutic Drug Delivery (Part I)
The development of a vector for the delivery of therapeutic drugs in a controlled and targeted fashion is still a major challenge in the treatment of many diseases. The conventional application of drugs may lead to many limitations including poor distribution, limited effectiveness, lack of selectivity and dose dependent toxicity. An efficient drug delivery system can address these problems. Recent nanotechnology advancements in the biomedical field have the potential to meet these challenges in developing drug delivery systems. Nanomaterials are changing the biomedical platform in terms of disease diagnosis, treatment and prevention. Nanomaterials aided drug delivery provides an advantage b...
The Design and Development of Novel Drugs and Vaccines
The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval. Covers both in silico methods and experimental protocols for vaccine and drug development in a single, accessible volume Offers a holistic accounting of how developments in bioinformatics and large experimental datasets can be used in the development of vaccines and drugs Shows researchers the entire gamut of current therapies, ranging from computational inputs to animal studies Reviews the most current, cutting-edge research available on vaccine and drug design and development
Nanomaterials: Evolution and Advancement towards Therapeutic Drug Delivery (Part II)
The development of a vector for the delivery of therapeutic drugs in a controlled and targeted fashion is still a major challenge in the treatment of many diseases. The conventional application of drugs may lead to many limitations including poor distribution, limited effectiveness, lack of selectivity and dose dependent toxicity. An efficient drug delivery system can address these problems. Recent nanotechnology advancements in the biomedical field have the potential to meet these challenges in developing drug delivery systems. Nanomaterials are changing the biomedical platform in terms of disease diagnosis, treatment and prevention. Nanomaterials aided drug delivery provides an advantage b...
Cancer Therapy
Herbal Medicine: Back to the Future compiles expert reviews on the application of herbal medicines (including Ayurveda, Chinese traditional medicines and alternative therapies) to treat different ailments. The book series demonstrates the use of sophisticated methods to understand traditional medicine, while providing readers a glimpse into the future of herbal medicine. This volume presents reviews of traditional Chinese medicine and other plant based therapies useful for treating different cancers. The topics included in this volume are: Herbal extracts from Carica papaya and Azadirachta Natural antimutagens Encapsulated polyphenols and other anticancer compounds derived from plants Traditional Chinese medicine treatments for cancer related fatigue Indirubins Ayurvedic anticancer herbal medicines Melanocyte regeneration through herbal medicine This volume is essential reading for all researchers in the field of natural product chemistry and pharmacology. Medical professionals involved in oncology who seek to improve their knowledge about herbal medicine and alternative therapies will also benefit from the contents of the volume.
Selected Topics in Nanomedicine
Nanomedicine consists of the use of nanotechnology and nanobiotechnology in medicine. There have been extensive developments in the area of nanomedicine. The scope of this book is first to discuss the origin of nanomedicine. Following this, instead of a general overview of the whole area, 24 chapters on selected topics of important areas are described in detail. Authors are selected from around the world to give a representative and international view of the activities in the area of nanomedicine. Contents:Artificial Cells: The Beginning of Nanomedicine (Thomas Ming Swi Chang)The Clinical Development of Hemopure®: A Selective Commentary (A Gerson Greenburg)Glutaraldehyde Polymerized Porcine...
Nanomaterials in the Battle Against Pathogens and Disease Vectors
Nanomaterials in the Battle Against Pathogens and Disease Vectors presents an overview of the use of nanotechnology to mitigate pathogens of concern, and is the first book to discuss applications of nanotechnology in the fight against all three major domains of disease-causing pathogens. Bacteria, viruses, and parasites constitute the list of emerging and re-emerging pathogens of high priority. Nanotechnology has proven to be a groundbreaking success in the elimination, targeted toxicity, precise immunogenicity, diagnosis, and imaging of these major pathogens and disease vectors. This text discusses basic concepts and advanced applications for bacteria, viruses, and parasites. It describes the use of metallic and non-metallic nanoparticles and nanotoxicity, as well as presents future applications of nanotechnology in biological applications. This work is ideal for engineers and scientists across the interdisciplinary fields of materials science, biomedical engineering, biotechnology, and others concerned with mitigating the risk and effect of pathogens.
