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Therapeutic Oligonucleotides
This book provides a compelling overall update on current status of RNA interference
A Practical Guide to Membrane Protein Purification
A Practical Guide to Membrane Protein Purification is written especially for researchers who have some familarity with separation of water-soluble proteins, but who may not be aware of the pitfalls they face with membrane proteins. This guide presents techniques in a concise form, emphasizing the aspects unique to membrane proteins. The book explains the principles of the methods, permitting researchers and students new to this area to adapt these techniques to their particular needs. The second volume in the series, this book is an essential manual for investigations of structure and function of native membrane proteins, as well as for purification of these proteins for immunization and pro...
Mitochondrial Biogenesis and Genetics
The critically acclaimed laboratory standard for forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerlyawaited, frequently consulted, and praised by researchers and reviewers alike. More than 250 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features * Structural and functional analysis of oxidative phosphorylation complexes * Import of proteins and RNA into mitochondria * Ion and metabolite transport systems in mitochondria * Biophysical methods for mitochondrial function analysis * Mitochondrial inheritance and turnover.
Metabolomics, Metabonomics and Metabolite Profiling
In this comprehensive resource the Editor draws together experts from the field and provides an insightful introduction into the technology and methodology.
Computational and Structural Approaches to Drug Discovery
1.-Facing the Wall in Computationally Based Approaches to Drug Discovery / Janet S. Finer-Moore and Jeff Blaney and Robert M. Stroud. 2.-The Changing Landscape in Drug Discovery / Hugo Kubinyi. 3.-Purine Nucleoside Phosphorylase / Yang Zhang and Steven E. Ealick. 4.-Application and Limitations of X-Ray Crystallographic Data in Structure-Guided Ligand and Drug Design / Andrew M. Davis and Simon J. Teague and Gerard J. Kleywegt. 5.-Dealing with Bound Waters in a Site: Do they Leave or Stay? / Donald Hamelberg and J. Andrew McCammon. 6.-Knowledge-Based Methods in Structure-Based Design / Marcel L. Verdonk and Wijnand T. M. Mooij. 7.-Combating Drug Resistance - Identifying Resilient Molecular Ta...
Sequence-specific DNA Binding Agents
The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the subject. Written by experts in the field, this book discusses diverse modes of binding of antibiotics and drugs to DNA, emphasising matters that are important or promising for cancer treatment. Chapters discuss established agents like actinomycin D but also look at novel drugs with strong potential in chemotherapy such as new topoisomerase inhibitors, telomerase inhibitors, peptide nucleic acids and triple helix-forming oligonucleotides. There are also sections discussing methodological advances including computational methods, slow kinetics, melting curve analysis and approaches to medicinal chemistry. Finally there is a section on RNA structure and its potential as a drug target. The book is ideal for researchers in industry and academia who require a comprehensive source of reference to this rapidly expanding subject.
Protein Folding, Misfolding and Aggregation
Protein folding and aggregation is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods h.
