You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Skin biopsy with a 3mm disposable circular punch is easy to perform and allows, after proper processing, the visualization of epidermal, dermal, and sweat gland nerve fibers. A technique of sampling the epidermis alone by applying a suction capsule, the “blister” technique, has also been developed. It is most common to stain immunohistochemically for the pan-axonal marker protein gene product 9.5 (PGP 9.5), an ubiquitin C-terminal hydroxylase. The sections are then observed and analyzed with bright-field microscopy or with indirect immunofluorescence with or without confocal microscopy. Most studies report quantification of intraepidermal nerve fiber density displayed in bright-field mic...
This book focuses on the important relationship between the heart and brain in medical practice. The brain and nervous system may cause or influence heart disease, for instance by causing arrhythmias or modifying the response to ischemia. Disorders of the heart and circulation may in turn cause brain damage, for instance by releasing emboli resulting in cerebral infarction. Frequently, the brain and heart are both targets of the same disease process. They both have electrophysiologically active cells, and the responses to these cells to disease and various interventions have several similarities. Many drugs affect both organs and have mutual negative side-effects. With the increasing subspecialization in medicine, it is important to offer a work that integrates basic and clinical aspects of cardiology, neurology, cerebrovascular surgery and neurosurgery. This cross-fertilization of subject areas will broaden horizons and advance both understanding and practice.
Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and conse...
None